Human DJ-1 is a genetic cause of early-onset Parkinson's disease (PD), although its
biochemical function is unknown. We report here that human DJ-1 and its homologs of the …

The physiological role of DJ-1, a protein involved in familial Parkinson disease is still
controversial. One of the hypotheses proposed indicates a sensor role for oxidative stress …

DJ‐1, a protein encoded by PARK7 plays a protective role against neurodegeneration.
Since its glyoxalase III activity catalyzing methylglyoxal (MG) to lactate was discovered, DJ‐1 …

Abstract DJ-1 (PARK7) is a multifunctional protein linked to the onset and progression of a
number of diseases, most of which are associated with high oxidative stress. The Cys106 of …

DJ-1 is a deglycase enzyme which exhibits a redox-sensitive chaperone-like activity. The
partially oxidized state of DJ-1 is active in inhibiting the aggregation of α-synuclein, a key …

DJ-1 was initially identified as a novel oncogene and has recently been found to be a
causative gene for a familial form of Parkinson's disease (PD), viz, PARK7. Cysteine residue …

Mutations in the protein DJ-1 cause recessive forms of early onset familial Parkinson's
disease (PD). To date, most of the causative mutations studied destabilize formation of DJ-1 …

Tau aggregate-bearing lesions are pathological markers and potential mediators of
tauopathic neurodegenerative diseases, including Alzheimer's disease. The molecular …

Sorafenib is the first‐line therapeutic regimen targeting against advanced or metastatic
stage of hepatocellular carcinoma (HCC). However, HCC patients at these stages will …

The loss of native function of the DJ-1 protein has been linked to the development of
Parkinson's (PD) and other neurodegenerative diseases. Here we show that DJ-1 …