Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes high
morbidity and mortality in cystic fibrosis (CF) and immunocompromised patients, including …

Erythropoietin (EPO) is a hypoxia-induced hormone produced in adult kidneys with
erythropoietic and non-erythropoietic effects. In vivo studies represent an important role to …

Due to (i) the uremia-enhanced sepsis severity,(ii) the high prevalence of sepsis with pre-
existing renal injury and (iii) the non-erythropoiesis immunomodulation of erythropoietin …

Abstract Background Polyclonal or IgM-enriched immunoglobulins may be beneficial during
sepsis as an adjuvant immunomodulatory therapy. We aimed to test whether the infusion of …

Septic gut damage is critical in the progression of sepsis and multiple organ failure,
characterized by gut microbiota dysbiosis and epithelium deficiency in the gut barrier …

Sepsis is a syndrome that includes physiological, pathological, and biochemical
abnormalities resulting from the host immune response to infection. Despite the improved …

This study aims to confirm the protective effect of Pentraxin 3 (PTX3) on intestinal mucosal
barrier damage in sepsis in animal and cell models and explore its mechanism. Analysis of …

Severe infections induce immune defense mechanisms and initial tissue damage, which
produce an inflammatory neutrophil response. Upon dysregulation of these responses …

Background Currently, the mechanisms of impaired gut mucosal immunity in sepsis remain
unclear. Gut immunoglobulin A (IgA) is an important defense mechanism against invasive …

Antibody-mediated allograft rejection (AMR) hinders patient prognosis after organ
transplantation. Current studies concerning AMR have mainly focused on the diagnostic …