TTD: Therapeutic Target Database describing target druggability information
Y Zhou, Y Zhang, D Zhao, X Yu, X Shen… - Nucleic acids …, 2024 - academic.oup.com
Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for developing first-in-class drug. A variety …
identification of promising targets is fundamental for developing first-in-class drug. A variety …
A specific phosphorylation-dependent conformational switch in SARS-CoV-2 nucleocapsid protein inhibits RNA binding
M Botova, AR Camacho-Zarco, J Tognetti… - Science …, 2024 - science.org
The nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 encapsidates
the viral genome and is essential for viral function. The central disordered domain comprises …
the viral genome and is essential for viral function. The central disordered domain comprises …
Protein–RNA interactions: from mass spectrometry to drug discovery
B Steinmetz, I Smok, M Bikaki… - Essays in Biochemistry, 2023 - portlandpress.com
Proteins and RNAs are fundamental parts of biological systems, and their interactions affect
many essential cellular processes. Therefore, it is crucial to understand at a molecular and …
many essential cellular processes. Therefore, it is crucial to understand at a molecular and …
Specific protein-RNA interactions are mostly preserved in biomolecular condensates
T de Vries, M Novakovic, Y Ni, I Smok, C Inghelram… - Science …, 2024 - science.org
Many biomolecular condensates are enriched in and depend on RNAs and RNA binding
proteins (RBPs). So far, only a few studies have addressed the characterization of the …
proteins (RBPs). So far, only a few studies have addressed the characterization of the …
A compact stem-loop DNA aptamer targets a uracil-binding pocket in the SARS-CoV-2 nucleocapsid RNA-binding domain
MA Esler, CA Belica, JA Rollie, WL Brown… - Nucleic acids …, 2024 - academic.oup.com
Abstract SARS-CoV-2 nucleocapsid (N) protein is a structural component of the virus with
essential roles in the replication and packaging of the viral RNA genome. The N protein is …
essential roles in the replication and packaging of the viral RNA genome. The N protein is …
RNA structure and multiple weak interactions balance the interplay between RNA binding and phase separation of SARS-CoV-2 nucleocapsid
AB Estelle, HM Forsythe, Z Yu, K Hughes… - PNAS …, 2023 - academic.oup.com
The nucleocapsid (N) protein of SARS-CoV-2 binds viral RNA, condensing it inside the
virion, and phase separating with RNA to form liquid–liquid condensates. There is little …
virion, and phase separating with RNA to form liquid–liquid condensates. There is little …
Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid
The viral genome of SARS-CoV-2 is packaged by the nucleocapsid (N-) protein into
ribonucleoprotein particles (RNPs), 38±10 of which are contained in each virion. Their …
ribonucleoprotein particles (RNPs), 38±10 of which are contained in each virion. Their …
A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding
K Dhamotharan, SM Korn, A Wacker… - Nature …, 2024 - nature.com
The SARS-CoV-2 nucleocapsid protein is indispensable for viral RNA genome processing.
Although the N-terminal domain (NTD) is suggested to mediate specific RNA-interactions …
Although the N-terminal domain (NTD) is suggested to mediate specific RNA-interactions …
[HTML][HTML] Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid
The viral genome of SARS-CoV-2 is packaged by the nucleocapsid (N-) protein into
ribonucleoprotein particles (RNPs), 38±10 of which are contained in each virion. Their …
ribonucleoprotein particles (RNPs), 38±10 of which are contained in each virion. Their …
Effect of the SARS-CoV-2 Delta-associated G15U mutation on the s2m element dimerization and its interactions with miR-1307-3p
The s2m, a highly conserved 41-nt hairpin structure in the SARS-CoV-2 genome, serves as
an attractive therapeutic target that may have important roles in the virus life cycle or …
an attractive therapeutic target that may have important roles in the virus life cycle or …