Antimicrobial peptides from plants

JP Tam, S Wang, KH Wong, WL Tan - Pharmaceuticals, 2015 - mdpi.com
Plant antimicrobial peptides (AMPs) have evolved differently from AMPs from other life
forms. They are generally rich in cysteine residues which form multiple disulfides. In turn, the …

Cyclotides: from structure to function

SJ De Veer, MW Kan, DJ Craik - Chemical reviews, 2019 - ACS Publications
This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Discovery, structure, function, and applications of cyclotides: circular proteins from plants

J Weidmann, DJ Craik - Journal of Experimental Botany, 2016 - academic.oup.com
Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

J Koehbach, M O'Brien… - Proceedings of the …, 2013 - National Acad Sciences
Cyclotides are plant peptides comprising a circular backbone and three conserved disulfide
bonds that confer them with exceptional stability. They were originally discovered in …

Site‐specific N‐terminal labeling of peptides and proteins using butelase 1 and thiodepsipeptide

GKT Nguyen, Y Cao, W Wang, CF Liu… - Angewandte …, 2015 - Wiley Online Library
An efficient ligase with exquisite site‐specificity is highly desirable for protein modification.
Recently, we discovered the fastest known ligase called butelase 1 from Clitoria ternatea for …

Cyclotides as grafting frameworks for protein engineering and drug design applications

AG Poth, LY Chan, DJ Craik - Peptide Science, 2013 - Wiley Online Library
Cyclotides are a family of naturally occurring backbone‐cyclized macrocyclic mini‐proteins
from plants that have a knotted trio of intramolecular disulfide bonds. Their structural features …

Computational tools for exploring sequence databases as a resource for antimicrobial peptides

WF Porto, AS Pires, OL Franco - Biotechnology advances, 2017 - Elsevier
Data mining has been recognized by many researchers as a hot topic in different areas. In
the post-genomic era, the growing number of sequences deposited in databases has been …

Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining

R Hellinger, J Koehbach, DE Soltis… - Journal of proteome …, 2015 - ACS Publications
Cyclotides are plant-derived mini proteins. They are genetically encoded as precursor
proteins that become post-translationally modified to yield circular cystine-knotted …

Insights into biological role of plant defense proteins: A review

M Jain, GM Amera, J Muthukumaran… - Biocatalysis and …, 2022 - Elsevier
Proteins are diverse class of organic molecules that are structural and functional unit of the
cell. The most important role of proteins is the defense against foreign molecules and …

Cyclotide discovery in Gentianales revisited—identification and characterization of cyclic cystine‐knot peptides and their phylogenetic distribution in Rubiaceae plants

J Koehbach, AF Attah, A Berger, R Hellinger… - Peptide …, 2013 - Wiley Online Library
Cyclotides are a unique class of ribosomally synthesized cysteine‐rich miniproteins
characterized by a head‐to‐tail cyclized backbone and three conserved disulfide‐bonds in a …