The placenta is a transient organ that forms during pregnancy to support the growth and
development of the fetus. During human placental development, trophoblast cells …

Citation Sharp AN, Heazell AEP, Crocker IP, Mor G. Placental apoptosis in health and
disease. Am J Reprod Immunol 2010; 64: 159–169 Apoptosis, programmed cell death, is an …

Background: During implantation, apoptosis is critical for the appropriate tissue remodeling
of the maternal decidua and invasion of the developing embryo, yet the regulation of …

Apoptosis is important for normal placental development, but it may also be involved in the
pathophysiology of pregnancy-related diseases. Normal placental development is …

Disruption of the mouse gene encoding the blood coagulation inhibitor thrombomodulin
(Thbd) leads to embryonic lethality caused by an unknown defect in the placenta. We show …

Placental apoptosis is increased in vivo in preeclampsia (PE) and intrauterine growth
restriction (IUGR). The cause and pathological implications of this phenomenon are …

The role of the maternal immune system during pregnancy has focused mainly on the aspect
of immune tolerance to the invading trophoblast and, therefore, fetus. While this is a critical …

The syncytiotrophoblast contains aggregates of nuclei termed syncytial knots. Increased
numbers of syncytial knots have been reported in placentae of pregnancies complicated by …

Objective: We tested the hypothesis that apoptotic trophoblasts from pregnancies associated
with fetal growth restriction caused by preeclampsia or cigarette use exhibit enhanced …

Hypoxia has been implicated in the pathogenesis of preeclampsia, a hypertensive disorder
of pregnancy. However, in vivo evidence and mechanistic understanding remain elusive …