Memory B cells
T Inoue, T Kurosaki - Nature Reviews Immunology, 2024 - nature.com
Recent advances in studies of immune memory in mice and humans have reinforced the
concept that memory B cells play a critical role in protection against repeated infections …
concept that memory B cells play a critical role in protection against repeated infections …
Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection
More than one year after its inception, the coronavirus disease 2019 (COVID-19) pandemic
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains difficult …
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains difficult …
IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells
Both B cell receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …
Germinal center–dependent and–independent memory B cells produced throughout the immune response
C Viant, T Wirthmiller, MA ElTanbouly… - Journal of Experimental …, 2021 - rupress.org
Memory B cells comprise a heterogenous group of cells that differ in origin and phenotype.
During the early phases of the immune response, activated B cells can differentiate into IgM …
During the early phases of the immune response, activated B cells can differentiate into IgM …
Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow
The longevity of plasma cells is dependent on their ability to access and reside in so-called
niches that are predominantly located in the bone marrow. Here, by employing a traceable …
niches that are predominantly located in the bone marrow. Here, by employing a traceable …
Germinal centers
GD Victora, MC Nussenzweig - Annual review of immunology, 2022 - annualreviews.org
Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody
affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification …
affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification …
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees
T Inoue, R Shinnakasu, C Kawai… - Journal of Experimental …, 2022 - rupress.org
In contrast to a second dose of the SARS-CoV-2 mRNA vaccine, a third dose elicits potent
neutralizing activity against the Omicron variant. To address the underlying mechanism for …
neutralizing activity against the Omicron variant. To address the underlying mechanism for …
[HTML][HTML] Interferon-γ production by Tfh cells is required for CXCR3+ pre-memory B cell differentiation and subsequent lung-resident memory B cell responses
NM Arroyo-Díaz, H Bachus, A Papillion, TD Randall… - Immunity, 2023 - cell.com
Lung-resident memory B cells (lung-BRMs) differentiate into plasma cells after reinfection,
providing enhanced pulmonary protection. Here, we investigated the determinants of lung …
providing enhanced pulmonary protection. Here, we investigated the determinants of lung …
Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge
W Shao, Y Wang, Q Fang, W Shi, H Qi - Nature Immunology, 2024 - nature.com
Memory B cells (MBCs) differentiate into plasma cells (PCs) or germinal centers (GCs) upon
antigen recall. How this decision is programmed is not understood. We found that the …
antigen recall. How this decision is programmed is not understood. We found that the …