Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …

Additive manufacturing techniques offer the potential to fabricate organized tissue constructs
to repair or replace damaged or diseased human tissues and organs. Using these …

Mimicking the anisotropic cardiac structure and guiding 3D cellular orientation play a critical
role in designing scaffolds for cardiac tissue regeneration. Significant advances have been …

The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel
system—the vascularization. In vivo almost all tissues are supplied by these endothelial cell …

The engineering of 3-dimensional (3D) heart muscles has undergone exciting progress for
the past decade. Profound advances in human stem cell biology and technology, tissue …

Twenty years after the initial description of a tissue engineered construct, 3-dimensional
human cardiac tissues of different kinds are now generated routinely in many laboratories …

There is enormous global anticipation for stem cell-based therapies that are safe and
effective. Numerous pre-clinical studies present encouraging results on the therapeutic …

In vitro fabrication of functional vascularized three-dimensional tissues has been a long-
standing objective in the field of tissue engineering. Here we report a technique to engineer …

The survival of engineered tissue constructs during the initial phase after their implantation
depends on the rapid development of an adequate vascularization. This, in turn, is a major …

Biofabrication of living structures with desired topology and functionality requires the
interdisciplinary effort of practitioners of the physical, life and engineering sciences. Such …