Intervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the
human lifespan that can increase the risk of low back pain. More clarification of the …

Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular
molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell …

The single‐atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary
catalytic activity. Here, we constructed a PEGylated manganese‐based SAE (Mn/PSAE) by …

Overcoming apoptosis resistance to achieve efficient breast cancer treatment remains a
challenge. The precise induction of another form of programmed cell death, pyroptosis, is an …

Ferroptosis is a necrotic form of regulated cell death that was associated with lipid
peroxidation and free iron‐mediated Fenton reactions. It has been reported that iron …

Background: The sodium-glucose co-transporter-2 (SGLT-2) inhibitor dapagliflozin improves
cardiovascular outcomes in patients with type 2 diabetes in a manner that is partially …

The biomechanical environment plays a dominant role in fracture healing, and Piezo1 is
regarded as a major mechanosensor in bone homeostasis. However, the role of Piezo1 in …

Necrosis that appears at the ischemic distal end of random-pattern skin flaps increases the
pain and economic burden of patients. Necroptosis is thought to contribute to flap necrosis …

Nanocatalytic medicine holds great potential in inhibiting tumor progression based on the
synergistic catalytic production of toxic reactive oxygen species (ROS) between fenton …

Excess iron has been reported to lead to osteoblastic cell damage, which is a crucial
pathogenesis of iron overload‐related osteoporosis. However, the cytotoxic mechanisms …