The unique anatomical and physiological connections between the nasal cavity and brain
provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted …

Zolmitriptan (ZT) is a potent second generation triptan, commonly administered to alleviate
migraine attacks. ZT suffers various limitations; massive hepatic first pass metabolism, P-gp …

The nose-to-brain drug-delivery system has emerged as a promising strategy to overcome
the challenges associated with conventional drug administration for central nervous system …

Otitis media is an acute illness that specifically targets the middle ear. It affects around one-
third of the pediatric population in the US. This study aimed to develop lecithin-based …

Candesartan cilexetil (CAN) is administered for treating hypertension and heart failure. CAN
suffers poor oral bioavailability, owing to limited aqueous solubility, and first-pass …

Clozapine (CZP) is an atypical antipsychotic, the most effective for the treatment of resistant
schizophrenia. With the aim of overcome the limitations of current dosage forms (tablets or …

Rizatriptan (RTP) is an anti-migraine drug and after oral administration, it exhibits low
bioavailability (45%) due to high first-pass hepatic metabolism. Therefore, to resolve this …

The complexity of treating neurological diseases has meant that new strategies have had to
be developed to deliver drugs to the brain more efficiently and safely. Intranasal drug …

Background/Objectives: Nintedanib (NTD), a triple tyrosine kinase receptor inhibitor, is the
recommended first-line tackling option for idiopathic pulmonary fibrosis (IPF). Nevertheless …

Self-assembled structures in highly biocompatible Natural Deep Eutectic Solvent (NADES)
are gaining popularity as new drug delivery systems due to their inherent advantages …