High-throughput glycomic methods

I Trbojević-Akmačić… - Chemical …, 2022 - ACS Publications
Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

Glycosylation in cancer: mechanisms and clinical implications

SS Pinho, CA Reis - Nature Reviews Cancer, 2015 - nature.com
Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

The tumour glyco-code as a novel immune checkpoint for immunotherapy

E RodrÍguez, STT Schetters, Y van Kooyk - Nature Reviews …, 2018 - nature.com
Tumour growth is accompanied by tumour evasion of the immune system, a process that is
facilitated by immune checkpoint molecules such as programmed cell death protein 1 (PD1) …

Global functions of O‐glycosylation: promises and challenges in O‐glycobiology

HH Wandall, MAI Nielsen, S King‐Smith… - The FEBS …, 2021 - Wiley Online Library
Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

[HTML][HTML] Aberrant sialylation in cancer: therapeutic opportunities

J Munkley - Cancers, 2022 - mdpi.com
Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

[HTML][HTML] Hallmarks of glycosylation in cancer

J Munkley, DJ Elliott - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …

Protein glycosylation in cancer

SR Stowell, T Ju, RD Cummings - Annual Review of Pathology …, 2015 - annualreviews.org
Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

[HTML][HTML] Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics

E Paleček, J Tkáč, M Bartosik, T Bertók… - Chemical …, 2015 - ACS Publications
The present advances in biology are related to progress in genomics, proteomics, and other
“-omics”, including glycomics, working with a large amount of data regarding human and …

[HTML][HTML] The convergence of traditional and digital biomarkers through AI-assisted biosensing: A new era in translational diagnostics?

SS Arya, SB Dias, HF Jelinek, LJ Hadjileontiadis… - Biosensors and …, 2023 - Elsevier
Advances in consumer electronics, alongside the fields of microfluidics and nanotechnology
have brought to the fore low-cost wearable/portable smart devices. Although numerous …

[HTML][HTML] Integrated proteomic and glycoproteomic characterization of human high-grade serous ovarian carcinoma

Y Hu, J Pan, P Shah, M Ao, SN Thomas, Y Liu, L Chen… - Cell reports, 2020 - cell.com
Many gene products exhibit great structural heterogeneity because of an array of
modifications. These modifications are not directly encoded in the genomic template but …