Hydrocephalus: historical analysis and considerations for treatment
Hydrocephalus is a serious condition that affects patients of all ages, resulting from a
multitude of causes. While the etiologies of hydrocephalus are numerous, many of the acute …
multitude of causes. While the etiologies of hydrocephalus are numerous, many of the acute …
The role of motile cilia in the development and physiology of the nervous system
C Ringers, EW Olstad… - … Transactions of the …, 2020 - royalsocietypublishing.org
Motile cilia are miniature, whip-like organelles whose beating generates a directional fluid
flow. The flow generated by ciliated epithelia is a subject of great interest, as defective ciliary …
flow. The flow generated by ciliated epithelia is a subject of great interest, as defective ciliary …
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus
Hydrocephalus, characterized by cerebral ventricular dilatation, is routinely attributed to
primary defects in cerebrospinal fluid (CSF) homeostasis. This fosters CSF shunting as the …
primary defects in cerebrospinal fluid (CSF) homeostasis. This fosters CSF shunting as the …
Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain
Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine
disorders. The development of ciliated cells, their impact on CSF flow, and their function in …
disorders. The development of ciliated cells, their impact on CSF flow, and their function in …
Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia
Motile cilia are hair-like cell extensions that beat periodically to generate fluid flow along
various epithelial tissues within the body. In dense multiciliated carpets, cilia were shown to …
various epithelial tissues within the body. In dense multiciliated carpets, cilia were shown to …
[HTML][HTML] Rethinking the cilia hypothesis of hydrocephalus
PQ Duy, ABW Greenberg, WE Butler, KT Kahle - Neurobiology of Disease, 2022 - Elsevier
Dysfunction of motile cilia in ependymal cells has been proposed to be a pathogenic cause
of cerebrospinal fluid (CSF) overaccumulation leading to ventricular expansion in …
of cerebrospinal fluid (CSF) overaccumulation leading to ventricular expansion in …
A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus
Hydrocephalus, characterized by cerebral ventriculomegaly, is the most common disorder
requiring brain surgery in children. Recent studies have implicated SMARCC1, a component …
requiring brain surgery in children. Recent studies have implicated SMARCC1, a component …
Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics
Enlargement of the cerebrospinal fluid (CSF)–filled brain ventricles (cerebral
ventriculomegaly), the cardinal feature of congenital hydrocephalus (CH), is increasingly …
ventriculomegaly), the cardinal feature of congenital hydrocephalus (CH), is increasingly …
Cerebrospinal fluid cavitation as a mechanism of blast-induced traumatic brain injury: a review of current debates, methods, and findings
Cavitation has gained popularity in recent years as a potential mechanism of blast-induced
traumatic brain injury (bTBI). This review presents the most prominent debates on cavitation; …
traumatic brain injury (bTBI). This review presents the most prominent debates on cavitation; …
Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus
Background Hydrocephalus (increased ventricular size due to CSF accumulation) is a
common finding in human ciliopathies and in mouse models with genetic depletion of the …
common finding in human ciliopathies and in mouse models with genetic depletion of the …