Vanadium is an element ubiquitously present in our planet's crust and thus there are several
organisms that use vanadium for activity or function of proteins. Examples are the vanadium …

Tyrosine-type site-specific recombinases (T-SSRs) have opened new avenues for the
predictable modification of genomes as they enable precise genome editing in heterologous …

Viral genomes are poorly annotated in metagenomic samples, representing an obstacle to
understanding viral diversity and function. Current annotation approaches rely on alignment …

The use of Cre recombinase to carry out conditional mutagenesis of transgenes and insert
DNA cassettes into eukaryotic chromosomes is widespread (1–9). Indeed, a PubMed search …

In this chapter, we provide an overview of the fundamental concepts of DNA transposition
mechanisms. Our aim is to emphasize basic themes and, in this effort, we will focus on …

Using small molecules to control the function of proteins in live cells with complete specificity
is highly desirable, but challenging. Here we report a small-molecule switch that can be …

Cre recombinase is a phage-derived enzyme that has found utility for precise manipulation
of DNA sequences. Cre recognizes and recombines pairs of loxP sequences characterized …

Transposable elements in eukaryotic organisms have historically been considered “selfish,”
at best conferring indirect benefits to their host organisms. The Starships are a recently …

Optogenetic tools can provide direct and programmable control of gene expression. Light-
inducible recombinases, in particular, offer a powerful method for achieving precise …

Precise temporally regulated protein function directs the highly complex processes that
make up embryo development. The zebrafish embryo is an excellent model organism to …