Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
A Neuberger, YA Trofimov, MV Yelshanskaya… - Nature …, 2023 - nature.com
The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in
human cancers. Despite increasing interest of pharmacological research in developing …
human cancers. Despite increasing interest of pharmacological research in developing …
Natural compounds interacting with nicotinic acetylcholine receptors: from low-molecular weight ones to peptides and proteins
D Kudryavtsev, I Shelukhina, C Vulfius, T Makarieva… - Toxins, 2015 - mdpi.com
Nicotinic acetylcholine receptors (nAChRs) fulfill a variety of functions making identification
and analysis of nAChR subtypes a challenging task. Traditional instruments for nAChR …
and analysis of nAChR subtypes a challenging task. Traditional instruments for nAChR …
Mutagenesis of α-conotoxins for enhancing activity and selectivity for nicotinic acetylcholine receptors
MW Turner, LA Marquart, PD Phillips, OM McDougal - Toxins, 2019 - mdpi.com
Nicotinic acetylcholine receptors (nAChRs) are found throughout the mammalian body and
have been studied extensively because of their implication in a myriad of diseases. α …
have been studied extensively because of their implication in a myriad of diseases. α …
PST-PRNA: prediction of RNA-binding sites using protein surface topography and deep learning
P Li, ZP Liu - Bioinformatics, 2022 - academic.oup.com
Motivation Protein–RNA interactions play essential roles in many biological processes,
including pre-mRNA processing, post-transcriptional gene regulation and RNA degradation …
including pre-mRNA processing, post-transcriptional gene regulation and RNA degradation …
Temperature-sensitive gating of TRPV1 channel as probed by atomistic simulations of its trans-and juxtamembrane domains
AO Chugunov, PE Volynsky, NA Krylov, DE Nolde… - Scientific reports, 2016 - nature.com
Heat-activated transient receptor potential channel TRPV1 is one of the most studied
eukaryotic proteins involved in temperature sensation. Upon heating, it exhibits rapid …
eukaryotic proteins involved in temperature sensation. Upon heating, it exhibits rapid …
SURFMAP: a software for mapping in two dimensions protein surface features
H Schweke, MH Mucchielli, N Chevrollier… - Journal of Chemical …, 2022 - ACS Publications
Molecular cartography using two-dimensional (2D) representation of protein surfaces has
been shown to be very promising for protein surface analysis. Here, we present SURFMAP …
been shown to be very promising for protein surface analysis. Here, we present SURFMAP …
Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels
YA Trofimov, NA Krylov, AS Minakov… - Communications …, 2024 - nature.com
Structural biology is solving an ever-increasing number of snapshots of ion channel
conformational ensembles. Deciphering ion channel mechanisms, however, requires …
conformational ensembles. Deciphering ion channel mechanisms, however, requires …
Mapping the underlying mechanisms of fibrinogen benzothiazole drug interactions using computational and experimental approaches
Three-dimensional conformational crystallographic binding-modes are of paramount
importance to understand the docking mechanism of protein-ligand interactions and to …
importance to understand the docking mechanism of protein-ligand interactions and to …
Modeling phase transitions in mixtures of β–γ lens crystallins
M Kastelic, YV Kalyuzhnyi, V Vlachy - Soft Matter, 2016 - pubs.rsc.org
We analyze the experimentally determined phase diagram of a γD–βB1 crystallin mixture.
Proteins are described as dumbbells decorated with attractive sites to allow inter-particle …
Proteins are described as dumbbells decorated with attractive sites to allow inter-particle …
High-affinity α-conotoxin PnIA analogs designed on the basis of the protein surface topography method
IE Kasheverov, AO Chugunov, DS Kudryavtsev… - Scientific Reports, 2016 - nature.com
Despite some success for small molecules, elucidating structure–function relationships for
biologically active peptides—the ligands for various targets in the organism—remains a …
biologically active peptides—the ligands for various targets in the organism—remains a …