Human genetic and immunological determinants of critical COVID-19 pneumonia
Q Zhang, P Bastard, A Cobat, JL Casanova - Nature, 2022 - nature.com
SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …
Human autoantibodies underlying infectious diseases
A Puel, P Bastard, J Bustamante… - Journal of Experimental …, 2022 - rupress.org
The vast interindividual clinical variability observed in any microbial infection—ranging from
silent infection to lethal disease—is increasingly being explained by human genetic and …
silent infection to lethal disease—is increasingly being explained by human genetic and …
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
J Manry, P Bastard, A Gervais… - Proceedings of the …, 2022 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR)
doubles with every 5 y of age from childhood onward. Circulating autoantibodies …
doubles with every 5 y of age from childhood onward. Circulating autoantibodies …
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
P Bastard, LB Rosen, Q Zhang, E Michailidis… - Science, 2020 - science.org
INTRODUCTION Interindividual clinical variability is vast in humans infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from silent infection to …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from silent infection to …
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical
outcomes ranging from asymptomatic to severe disease and death. We previously reported …
outcomes ranging from asymptomatic to severe disease and death. We previously reported …
Detection of interferon alpha protein reveals differential levels and cellular sources in disease
Type I interferons (IFNs) are essential mediators of antiviral responses. These cytokines
have been implicated in the pathogenesis of autoimmunity, most notably systemic lupus …
have been implicated in the pathogenesis of autoimmunity, most notably systemic lupus …
Type I interferons and SARS-CoV-2: from cells to organisms
Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay
between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro …
between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro …
Guarding the frontiers: the biology of type III interferons
A Wack, E Terczyńska-Dyla, R Hartmann - Nature immunology, 2015 - nature.com
Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …
[HTML][HTML] JAK inhibitors and COVID-19
G Levy, P Guglielmelli, P Langmuir… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Abstract During SARS-CoV-2 infection, the innate immune response can be inhibited or
delayed, and the subsequent persistent viral replication can induce emergency signals that …
delayed, and the subsequent persistent viral replication can induce emergency signals that …
Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression
Introduction Many genetic variants associated with common disease susceptibility occur
close to immune-related genes in noncoding DNA, suggestive of a regulatory function. The …
close to immune-related genes in noncoding DNA, suggestive of a regulatory function. The …