Phage-encoded endolysins

F Abdelrahman, M Easwaran, OI Daramola, S Ragab… - Antibiotics, 2021 - mdpi.com
Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …

Enzymes and mechanisms employed by tailed bacteriophages to breach the bacterial cell barriers

S Fernandes, C São-José - Viruses, 2018 - mdpi.com
Monoderm bacteria possess a cell envelope made of a cytoplasmic membrane and a cell
wall, whereas diderm bacteria have and extra lipid layer, the outer membrane, covering the …

[HTML][HTML] Bacteriophage-encoded enzymes destroying bacterial cell membranes and walls, and their potential use as antimicrobial agents

Ł Grabowski, K Łepek, M Stasiłojć… - Microbiological …, 2021 - Elsevier
Appearance of pathogenic bacteria resistant to most, if not all, known antibiotics is currently
one of the most significant medical problems. Therefore, development of novel antibacterial …

Metagenome data on intestinal phage-bacteria associations aids the development of phage therapy against pathobionts

K Fujimoto, Y Kimura, M Shimohigoshi, T Satoh… - Cell host & …, 2020 - cell.com
The application of bacteriophages (phages) is proposed as a highly specific therapy for
intestinal pathobiont elimination. However, the infectious associations between phages and …

[HTML][HTML] Bacteriophage usage for bacterial disease management and diagnosis in plants

NT Vu, CS Oh - The Plant Pathology Journal, 2020 - ncbi.nlm.nih.gov
In nature, plants are always under the threat of pests and diseases. Pathogenic bacteria are
one of the major pathogen types to cause diseases in diverse plants, resulting in negative …

Thousands of novel endolysins discovered in uncultured phage genomes

I Fernández-Ruiz, FH Coutinho… - Frontiers in …, 2018 - frontiersin.org
Bacteriophages express endolysins toward the end of their replication cycle to degrade the
microbial cell wall from within, allowing viral progeny to be released. Endolysins can also …

An intramolecular cross-talk in D29 mycobacteriophage endolysin governs the lytic cycle and phage-host population dynamics

G Nair, V Jain - Science Advances, 2024 - science.org
D29 mycobacteriophage encodes LysA endolysin, which mediates mycobacterial host cell
lysis by targeting its peptidoglycan layer, thus projecting itself as a potential therapeutic …

An Endolysin LysSE24 by Bacteriophage LPSE1 Confers Specific Bactericidal Activity against Multidrug-Resistant Salmonella Strains

Y Ding, Y Zhang, C Huang, J Wang, X Wang - Microorganisms, 2020 - mdpi.com
Salmonella is responsible for a wide range of infections and is a constant threat to public
health, particularly in light of emerging antibiotic resistance. The use of bacteriophages and …

[HTML][HTML] A comparative guide to expression systems for phage lysin production

E Cremelie, R Vázquez, Y Briers - Essays in Biochemistry, 2024 - portlandpress.com
Phage lysins, bacteriophage-encoded enzymes tasked with degrading their host's cell wall,
are increasingly investigated and engineered as novel antibacterials across diverse …

Phages and their lysins: Toolkits in the battle against foodborne pathogens in the postantibiotic era

Z Huang, Z Zhang, J Tong, PK Malakar… - … Reviews in Food …, 2021 - Wiley Online Library
Worldwide, foods waste caused by putrefactive organisms and diseases caused by
foodborne pathogens persist as public health problems even with a plethora of modern …