What urologists need to know about ketamine‐induced uropathy: a systematic review

D Castellani, GM Pirola, M Gubbiotti… - Neurourology and …, 2020 - Wiley Online Library
Aims Ketamine is a general anesthetic. Dissociative effects and low cost led ketamine
becoming an illegal recreational drug in young adults. Ketamine‐induced uropathy (KIU) is …

A systematic review of therapeutic approaches used in experimental models of interstitial cystitis/bladder pain syndrome

T Kuret, D Peskar, A Erman, P Veranič - Biomedicines, 2021 - mdpi.com
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic bladder
disorder with limited therapeutic options currently available. The present review provides an …

Safety of human embryonic stem cell-derived mesenchymal stem cells for treating interstitial cystitis: a phase I study

JH Shin, CM Ryu, HY Yu, J Park… - Stem Cells …, 2022 - academic.oup.com
There are still no definite treatment modalities for interstitial cystitis (IC). Meanwhile, stem
cell therapy is rising as potential alternative for various chronic diseases. This study aimed to …

[HTML][HTML] Longitudinal intravital imaging of transplanted mesenchymal stem cells elucidates their functional integration and therapeutic potency in an animal model of …

CM Ryu, HY Yu, HY Lee, JH Shin, S Lee, H Ju… - Theranostics, 2018 - ncbi.nlm.nih.gov
Rationale: Mesenchymal stem cell (MSC) therapy may be a novel approach to improve
interstitial cystitis/bladder pain syndrome (IC/BPS), an intractable disease characterized by …

Current and future directions of stem cell therapy for bladder dysfunction

JH Shin, CM Ryu, HY Yu, DM Shin… - Stem Cell Reviews and …, 2020 - Springer
Stem cells are capable of self-renewal and differentiation into a range of cell types and
promote the release of chemokines and progenitor cells necessary for tissue regeneration …

[HTML][HTML] Intravital imaging and single cell transcriptomic analysis for engraftment of mesenchymal stem cells in an animal model of interstitial cystitis/bladder pain …

HY Yu, S Lee, H Ju, Y Kim, JH Shin, HD Yun, CM Ryu… - Biomaterials, 2022 - Elsevier
Mesenchymal stem cell (MSC) therapy is a promising treatment for various intractable
disorders including interstitial cystitis/bladder pain syndrome (IC/BPS). However, an analysis …

N-acetylcysteine prevents bladder tissue fibrosis in a lipopolysaccharide-induced cystitis rat model

CM Ryu, JH Shin, HY Yu, H Ju, S Kim, J Lim, J Heo… - Scientific Reports, 2019 - nature.com
Therapeutic options for non-Hunner type interstitial cystitis (IC), which is histologically
characterized by fibrosis and mast cell infiltration, are limited. We developed a rat model that …

A preclinical study of human embryonic stem cell-derived mesenchymal stem cells for treating detrusor underactivity by chronic bladder ischemia

HY Yu, JH Shin, HD Yun, CM Ryu, S Lee, J Heo… - Stem cell reviews and …, 2021 - Springer
Background The therapeutic effects of human embryonic stem cell-derived multipotent
mesenchymal stem cells (M-MSCs) were evaluated for detrusor underactivity (DUA) in a rat …

Mesenchymal stem cell therapy inhibited inflammatory and profibrotic pathways induced by partial bladder outlet obstruction and prevented high-pressure urine …

B Wiafe, AB Adesida, T Churchill, R Kadam… - Journal of Pediatric …, 2019 - Elsevier
Background Partial bladder outlet obstruction (pBOO) is characterized by an initial
inflammatory response that progresses to smooth muscle hypertrophy and fibrosis. Current …

Rodent models of ketamine‐induced cystitis

S Sultana, G Berger, A Cox, MEM Kelly… - Neurourology and …, 2021 - Wiley Online Library
Aims Long‐term or recreational use of ketamine affects the urinary system and can result in
ketamine‐induced cystitis (KIC). Rodent models of KIC are important to study KIC …