The hormone receptor oestrogen receptor-α (ER) orchestrates physiological mammary
gland development, breast carcinogenesis and the progression of breast tumours into lethal …

Androgens and estrogens are known to be critical regulators of mammalian physiology and
development. While these two classes of steroids share similar structures (in general …

The role of the androgen receptor (AR) in estrogen receptor (ER)-α-positive breast cancer is
controversial, constraining implementation of AR-directed therapies. Using a diverse …

Breast cancer (BC) is a hormone-related tumor. Despite the progress in BC therapy, this
disease still remains the most common cancer amongst women around the world. This is …

Abstract Estrogen receptor-positive (ER+) breast cancer accounts for approximately 75% of
all breast cancers. Endocrine therapies, including selective ER modulators (SERMs) …

The role of androgen receptor (AR) activation and expression is well understood in prostate
cancer. In breast cancer, expression and activation of AR is increasingly recognized for its …

Estrogen receptor α (ER) is the major driver of∼ 75% of breast cancers, and multiple ER
targeting drugs are routinely used clinically to treat patients with ER+ breast cancer …

Background Breast cancer (BC) has the highest cancer incidence and mortality in women
worldwide. Observational epidemiological studies suggest a positive association between …

Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …

Sex steroids have been widely described to be associated with a number of human
diseases, including hormone-dependent tumors. Several studies have been concerned …