Many tumor cells become resistant to commonly used cytotoxic drugs due to the
overexpression of ATP-binding cassette (ABC) transporters, namely P-glycoprotein (P-gp) …

One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR),
where cancer cells simultaneously become resistant to different anticancer drugs. Over …

Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial
pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge …

The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the
pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin …

Here, we review potential determinants of the anticancer efficacy of innate immune peptides
(ACPs) for cancer cells. These determinants include membrane‐based factors, such as …

The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …

An attractive strategy to overcome multidrug resistance in cancer chemotherapy is to
suppress P-glycoprotein (P-gp), which is a pump overproduced in cancer cells to remove …

Ovarian cancer patients frequently develop resistance to chemotherapy regiments using
Taxol and carboplatin. One of the resistance factors that protects cancer cells from Taxol …

Gastric cancer is one of the most common malignant tumors in the world. In China, its
morbidity and mortality are second only to lung cancer. Chemotherapy combined with …

In this text, the small team of expert authors presents the field in a comprehensive and
accessible manner that is well suited for students and junior researchers. The result is a …