▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

The neurotrophins, of which nerve growth factor (NGF) is the best known example, support
the survival and differentiation of chick embryo sensory neurons at extremely low …

Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be
distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and …

A variety of findings seem to functionally link brainderived neurotrophic factor (BDNF))'and
neurotrophin3 (NT-3), while distinguishing both of these factors from the third member of the …

Evolutionary conservation of members of the NGF family in vertebrates was studied by DNA
sequence analysis of PCR fragments for NGF, BDNF, and NT-3 from human, rat, chicken …

Epidermal keratinocytes (skin cells) are highly specialized epithelial cells designed to
perform a very specific function, separation of the organism from its environment. To …

Nerve growth factor (NGF) and its receptor are important in the development of cells derived
from the neural crest. Mouse L cell transformants have been generated that stably express …

The PC12 clone, developed from a pheochromocytoma tumor of the rat adrenal medulla,
has become a premiere model for the study of neuronal differentiation. When treated in …

Cellular diversity in the nervous system evolves from the concerted processes of cell
proliferation, differentiation, migration, survival, and synapse formation. Neural adhesion …

The role of the low affinity neurotrophin receptor, p75LNT', in NGF-mediated signal
transduction has been examined. Our results show that treatment of PC12 cells with MC192 …