Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

In clinical trials, biochemical markers provide useful information on the drug's mode of
action, therapeutic response and side effect monitoring and can act as surrogate endpoints …

Sarcopenia, a geriatric syndrome that is characterized by a progressive and generalized
skeletal muscle disorder, can be associated with many comorbidities, including obesity …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

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Aging results in a progressive decline in skeletal muscle mass, strength and function, a
condition known as sarcopenia. This pathological condition is due to multifactorial …

Disorders of cardiomyocyte metabolism play a crucial role in many cardiovascular diseases,
such as myocardial infarction, heart failure and ischemia–reperfusion injury. In myocardial …

The term “inflammageing” was introduced in 2000, with the aim of describing the chronic
inflammatory state typical of elderly individuals, which is characterized by a combination of …