The self-renewal and differentiation capacities of human pluripotent stem cells (hPSCs)
make them a promising source of material for cell transplantation therapy, drug …

Genome integrity of induced pluripotent stem cells (iPSCs) has been extensively studied in
recent years, but it is still unclear whether iPSCs contain more genomic variations than …

Cancer cells and stem cells share many traits, including a tendency towards genomic
instability. Human cancers exhibit tumor-specific genomic aberrations, which often affect …

The application of human embryonic stem cell (hESC) derivatives to regenerative medicine
is now becoming a reality. Although the vast majority of hESC lines have been derived for …

A detailed understanding of the developmental substates of human pluripotent stem cells
(hPSCs) is needed to optimize their use in cell therapy and for modeling early development …

Background Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in
the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with …

Neurodevelopmental disorders are characterized by an abnormal development of the
central nervous system, leading to a myriad of symptoms and diseases, including intellectual …

This chapter addresses the genetic instability in stem cells, a central feature that is an
important determinant for the safety and effectiveness of cell-based therapies. First, DNA …

Recent advances in mapping the complex genetic architecture underlying various
debilitatingbrain disorders have enabled identification of several genetic risk variants …

Human embryonic stem cells (hESCs) provide an essential tool to investigate early human
development, study disease pathogenesis, and examine therapeutic interventions …