Diabetes mellitus has been recognised as one of the four major non-communicable
diseases that demands urgent attention from all key shareholders globally in an effort to …

Oxidative stress is a critical factor in the pathogenesis and progression of diabetes and its
associated complications. The imbalance between reactive oxygen species (ROS) …

The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In
this process, tyrosine hydroxylase (TH) is the rate-limiting enzyme that hydroxylates tyrosine …

Berberine, an isoquinoline alkaloid isolated from the Chinese herb Coptis chinensis and
other Berberis plants, has a wide range of pharmacological properties. Berberine can be …

Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide,
underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is …

The increased incidence of metabolic diseases (eg, diabetes and obesity) has seriously
affected human health and life safety worldwide. It is of great significance to find effective …

Abstract Trimethylamine-N-oxide (TMAO) derived from the gut microbiota is an atherogenic
metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO …

Berberine is an isoquinoline alkaloid present in several plants, including Coptis sp. and
Berberis sp. Berberine is a customary component in Chinese medicine, and is characterized …

Abstract Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite
trimethylamine (TMA), has been identified to be an independent risk factor for promoting …

Berberine (BBR) is an isoquinoline plant alkaloid endowed with several pharmacological
activities, including anti-microbial, glucose-and cholesterol-lowering, anti-tumoral and …