H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …

The fields of application of functional proteomics are not limited to the study of protein–
protein interactions; they also extend to those involving protein complexes that bind DNA or …

Although the gain of function (GOF) of p53 mutants is well recognized, it remains unclear
whether different p53 mutants share the same cofactors to induce GOFs. In a proteomic …

Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack
of effective therapy preventing aortic rupture. During AAA formation, pathological vascular …

CCCTC-binding factor (CTCF) and cohesin are key players in three-dimensional chromatin
organization. The topologically associating domains (TADs) demarcated by CTCF are …

The nucleolus is a compartmentalized organelle in eukaryotic cells known to form during
embryogenesis, yet how its layered architecture is transformed from homogenous precursor …

Macrophage plasticity is critical for normal tissue repair to ensure transition from the
inflammatory to the proliferative phase of healing. We examined macrophages isolated from …

Breast cancer is the most common cancer affecting women worldwide. Many genes are
involved in the development of breast cancer, including the Kruppel Like Factor 12 (KLF12) …

Background Bivalent chromatin is an exemplar of epigenetic plasticity. This co-occurrence of
active-associated H3K4me3 and inactive-associated H3K27me3 histone modifications on …

The epigenome consists of all the epigenetic alterations like DNA methylation, the histone
modifications and non-coding RNAs which change the gene expression and have a role in …