Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …

Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy.
Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Cancer stem cells (CSCs) have been proposed as the driving force of tumorigenesis and the
seeds of metastases. However, their existence and role remain a topic of intense debate …

Despite the presence of mutations in APC or β-catenin, which are believed to activate the
Wnt signalling cascade constitutively, most colorectal cancers show cellular heterogeneity …

Tumors are being increasingly perceived as abnormal organs that, in many respects,
recapitulate the outgrowth and differentiation patterns of normal tissues. In line with this idea …

Glioblastoma multiforme (GBM) is a grade IV brain tumor characterized by a heterogeneous
population of cells that are highly infiltrative, angiogenic and resistant to chemotherapy. The …

Cancer stem cells (CSCs) are a subset of cancer cells which play a key role in predicting the
biological aggressiveness of cancer due to its ability of self-renewal and multi-lineage …

The recently developed concept of cancer stem cells (CSC) sheds new light on various
aspects of tumor growth and progression. Here, we present a mathematical model of …

Brain tumors, which are typically very heterogeneous at the cellular level, appear to have a
stem cell foundation. Recently, investigations from multiple groups have found that human …