Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …

Cells possess an extensive network of components to safeguard proteome integrity and
maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines …

Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …

Advances in sequencing and high-throughput techniques have provided an unprecedented
opportunity to interrogate human diseases on a genome-wide scale. The list of disease …

The biological functions of proteins are governed by their three-dimensional fold. Protein
folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically …

Stress induced by accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a
classic feature of secretory cells and is observed in many tissues in human diseases …

GRP78/BiP is a major endoplasmic reticulum (ER) chaperone protein critical for protein
quality control of the ER, as well as controlling the activation of the ER-transmembrane …

In this article, we will cover the folding of proteins in the lumen of the endoplasmic reticulum
(ER), including the role of three types of covalent modifications: signal peptide removal, N …

A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at
the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter …

The field of endoplasmic reticulum (ER) stress in mammalian cells has expanded rapidly
during the past decade, contributing to understanding of the molecular pathways that allow …