Inflammation is among the core causatives of male infertility. Despite male infertility being a
serious global issue,“bits and pieces” of its complex etiopathology still remain missing …

Background Varicocele (VC) is present in 35-40% of men with infertility. However, current
surgical and antioxidant treatments are not completely effective. In addition to oxidative …

The mammalian testis possesses a special immunological environment because of its
properties of remarkable immune privilege and effective local innate immunity. Testicular …

Zika virus (ZIKV) persists in the semen of male patients, a first for flavivirus infection. Here,
we demonstrate that ZIKV can induce inflammation in the testis and epididymidis, but not in …

The testis presents a special immunological environment, considering its property of
immune privilege that tolerates allo-and auto-antigens. Testicular immune privilege was …

The male genital tract (MGT) is the target of a number of viral infections that can have
deleterious consequences at the individual, offspring, and population levels. These …

Leydig cells are essential for steroidogenesis and spermatogenesis. An imbalance in the
production of reactive oxygen species (ROS) and the cellular antioxidant level brings about …

In recent years, several studies have analyzed the composition of the male genital tract
microbiota and its changes in infertility or in different situations associated with infertility. The …

Inflammation, both acute and chronic, is associated with testosterone deficiency, raising the
possibility of a direct causal link. One potential trigger for inflammation in obese men is the …

The mammalian testis possesses a unique immune environment that is essential for
testicular function. The testis is a remarkable immunoprivileged site that protects …