We identified 4-fluoro-N-[4-[6-(isopropylamino) pyrimidin-4-yl]-1, 3-thiazol-2-yl]-N-
methylbenzamide 27 as a potent mGluR1 antagonist. The compound possessed excellent …

This Review summarizes the medicinal chemistry found in publications on both orthosteric
and allosteric modulators of the metabotropic glutamate receptor 1 (mGlu1) from 2005 to the …

Recent progress in the discovery of mGlu1 allosteric modulators has suggested the
modulation of mGlu1 could offer possible treatment for a number of central nervous system …

A one-pot synthesis of ethers derived from inosine, guanosine, 2′-deoxyguanosine, and
pyrimidinones is described. Exposure of the heterocycle to 1 H-benzotriazol-1-yloxy-tris …

Metabotropic glutamate (mGlu) receptors (nomenclature as agreed by the NC-IUPHAR
Subcommittee on Metabotropic Glutamate Receptors [351]) are a family of G protein …

Metabotropic glutamate receptor 1 (mG luR1) is considered as an attractive drug target for
neuropathic pain treatments. The hierarchical virtual screening approach for identifying …

Development of SAR in an N-acyl-N′-arylpiperazine series of negative allosteric
modulators of mGlu1 using a functional cell-based assay is described in this Letter …

Development of glutamate non-competitive antagonists of mGluR1 (Metabotropic glutamate
receptor subtype 1) has increasingly attracted much attention in recent years due to their …

A new and efficient method for the synthesis of quinazolines has been developed. Thus, N‐
[2‐(1‐azidoalkyl) phenyl] formamides 1 are dehydrated with POCl3 to give the …

There has been much attention to discover mGluR1 antagonists for treating various central
nervous system diseases such as seizures and neuropathic pain. Thienopyrimidinone …