Despite the therapeutic success of monoclonal antibodies (mAbs), early identification of
developable mAb drug candidates with optimal manufacturability, stability, and delivery …

Protein molecules associate in solution, often in clusters beyond pairwise, leading to liquid
phase separations and high viscosities. It is often impractical to study these multi-protein …

The use of microfluidics to make mechanical property measurements is increasingly
common. Fabrication of microfluidic devices has enabled various types of flow control and …

Predicting the solution viscosity of monoclonal antibody (mAb) drug products remains as
one of the main challenges in antibody drug design, manufacturing, and delivery. In this …

Attractive protein–protein interactions in concentrated monoclonal antibody (mAb) solutions
may lead to the formation of clusters that increase viscosity. Here, we propose an analytical …

The effects of a subclass of monoclonal antibodies (mAbs) on protein–protein interactions,
formation of reversible oligomers (clusters), and viscosity (η) are not well understood at high …

Protein solution viscosity (η) as a function of temperature was measured at a series of
protein concentrations under a range of formulation conditions for two monoclonal …

Self-association of therapeutic monoclonal antibodies (mabs) are thought to modulate the
undesirably high viscosity observed in their concentrated solutions. Computational …

Antibody therapies are typically based on high-concentration formulations that need to be
administered subcutaneously. These conditions induce several challenges, inter alia a …

Understanding protein–protein interactions in concentrated therapeutic monoclonal
antibody (mAb) solutions is desirable for improved drug discovery, processing, and …