A novel 3'tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer

H Cui, H Li, H Wu, F Du, X Xie, S Zeng, Z Zhang… - Cell Death & …, 2022 - nature.com
At present, it is commonly believed that tRFs and tiRNAs are formed by the specific and
selective shear of tRNAs under certain pressure stimulation, rather than by random …

Emerging role of ZBTB7A as an oncogenic driver and transcriptional repressor

S Gupta, AK Singh, KS Prajapati, PP Kushwaha… - Cancer letters, 2020 - Elsevier
ZBTB7A is a member of the POK family of transcription factors that possesses a POZ-domain
at the N-terminus and Krüppel-like zinc-finger at the c-terminus. ZBTB7A was initially …

[HTML][HTML] The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases

L Cristiano - Genes & Diseases, 2022 - Elsevier
The eukaryotic translation elongation factors (EEFs), ie EEF1A1, EEF1A2, EEF1B2, EEF1D,
EEF1G, EEF1E1 and EEF2, are coding-genes that play a central role in the elongation step …

NuRD complex recruitment to Thpok mediates CD4+ T cell lineage differentiation

Y Gao, M Zamisch, M Vacchio, L Chopp, T Ciucci… - Science …, 2022 - science.org
Although BTB–zinc finger (BTB-ZF) transcription factors control the differentiation of multiple
hematopoietic and immune lineages, how they function is poorly understood. The BTB-ZF …

Role of LRF/Pokemon in lineage fate decisions

A Lunardi, J Guarnerio, G Wang… - Blood, The Journal …, 2013 - ashpublications.org
In the human genome, 43 different genes are found that encode proteins belonging to the
family of the POK (poxvirus and zinc finger and Krüppel)/ZBTB (zinc finger and broad …

Endoplasmic reticulum chaperone glucose regulated protein 170–Pokemon complexes elicit a robust antitumor immune response in vivo

B Yuan, R Xian, X Wu, J Jing, K Chen, G Liu, Z Zhou - Immunobiology, 2012 - Elsevier
Previous evidence suggested that the stress protein grp170 can function as a highly efficient
molecular chaperone, binding to large protein substrates and acting as a potent vaccine …

MiRNA153 reduces effects of chemotherapeutic agents or small molecular kinase inhibitor in HCC cells

Y Chen, F Feng, X Gao, C Wang, H Sun… - Current Cancer Drug …, 2015 - ingentaconnect.com
MicroRNA-153 (miR-153) is considered to be a tumor regulator. Silencing of miR-153
expression induced apoptosis in breast cancer cells. Data on mechanism suggest that up …

eEF1A phosphorylation in the nucleus of insulin-stimulated C2C12 myoblasts

M Piazzi, A Bavelloni, I Faenza, W Blalock… - Molecular & Cellular …, 2010 - ASBMB
Recent data indicate that some PKC isoforms are translocated to the nucleus, in response to
certain stimuli, where they play an important role in nuclear signaling events. To identify …

Opposing roles of C/EBPα and eEF1A1 in Sp1-regulated miR-122 transcription

C Zeng, Y Sang, FY Wang, SM Zhuang - RNA biology, 2020 - Taylor & Francis
We previously showed that miR-122 was frequently downregulated in hepatocellular
carcinoma (HCC) and C/EBPα transactivated miR-122 expression. In this study, we found …

Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers

M Andrea, T Weinschenk, S Colette, O Schoor… - US Patent …, 2018 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …