Ischemic disease is a class of diseases in which an organ is ischemic due to vascular
occlusion, a major contributor to death and disability worldwide. However, when the blood …

Abstract Background Prostate cancer (PCa) is one of the most common cancers worldwide
and oxidative stress is involved in its occurrence, development and progression. In fact, in …

Cancer is one of the most complex and systemic diseases affecting the health of mankind,
causing major deaths with a significant increase. This pathology is caused by several risk …

Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid
2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine …

Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3
(STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently …

Background The corosolic acid (CA), also known as plant insulin, is a pentacyclic
triterpenoid extracted from plants such as Lagerstroemia speciosa. It has been shown to …

Cardiovascular diseases (CVDs) are closely linked to cellular oxidative stress and
inflammation. This may be resulted from the imbalance generation of reactive oxygen …

Colorectal cancer remains a leading malignancy in humans. The importance of epigenetic
modification in the development of this disease is now being recognized. The reversible and …

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) and its negative
regulator kelch-like ECH-associated protein 1 (KEAP1) regulate various genes involved in …

Triterpenoids are a powerful group of phytochemicals derived from plant foods and herbs.
Many reports have shown that they possess chemopreventive and chemotherapeutic effects …