Enantiopure diarylmethanols and diarylmethylamines are important intermediates for the
synthesis of pharmaceutically relevant products with antihistaminic, antiarrhythmic, diuretic …

Pyridine derivatives are one of the most important moieties in the synthesis of various
biologically active compounds containing heterocyclic ring. But, due to the low reactivity of …

Protein stability and evolvability influence each other. Although protein dynamics play
essential roles in various catalytically important properties, their high flexibility and diversity …

Chiral propargylic boron compounds have a diverse array of potential applications. Although
numbers of highly enantioselective methodologies for the synthesis of other organoboron …

Directed evolution of enzymes for the asymmetric reduction of prochiral ketones to produce
enantio‐pure secondary alcohols is particularly attractive in organic synthesis. Loops …

A facile asymmetric transfer hydrogenation of ortho-substituted aryl N-heteroaryl ketones
and non-ortho-substituted N-oxide of aryl N-heteroaryl ketones using a readily available oxo …

The synthesis of diarylmethanols via the reduction of a range of substituted benzophenone
and benzoylpyridine derivatives with ketoreductase enzymes (KREDs) has afforded chiral …

A hydroclassified combinatorial saturation mutagenesis (HCSM) strategy was proposed for
reshaping the substrate binding pocket by dividing 20 amino acids into four groups based …

The catalytic asymmetric addition of aryl groups to aldehydes has generated an enormous
amount of attention.[1] The resulting diarylmethanols are important constituents of …

A new process has been developed for the highly enantioselective catalytic reduction of 2-
aroylpyridines and successfully applied to the synthesis of (S)-carbinoxamine (1), a …