Extracellular vesicles: delivery vehicles of myokines

E Trovato, V Di Felice, R Barone - Frontiers in physiology, 2019 - frontiersin.org
Movement and regular physical activity are two important factors that help the human body
prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart …

Brain-derived neurotrophic factor dysregulation as an essential pathological feature in Huntington's disease: mechanisms and potential therapeutics

A Speidell, N Bin Abid, H Yano - Biomedicines, 2023 - mdpi.com
Brain-derived neurotrophic factor (BDNF) is a major neurotrophin whose loss or interruption
is well established to have numerous intersections with the pathogenesis of progressive …

Moderate exercise combined with enriched environment enhances learning and memory through BDNF/TrkB signaling pathway in rats

L Xu, L Zhu, L Zhu, D Chen, K Cai, Z Liu… - International journal of …, 2021 - mdpi.com
This study aimed to investigate the effects and potential mechanisms of exercise combined
with an enriched environment on learning and memory in rats. Forty healthy male Wistar rats …

Exposure to RF-EMF alters postsynaptic structure and hinders neurite outgrowth in developing hippocampal neurons of early postnatal mice

JH Kim, KH Chung, YR Hwang, HR Park… - International Journal of …, 2021 - mdpi.com
Exposure to radiofrequency electromagnetic fields (RF-EMFs) has increased rapidly in
children, but information on the effects of RF-EMF exposure to the central nervous system in …

Neuroplasticity and neuroprotective effect of treadmill training in the chronic mouse model of Parkinson's disease

E Palasz, W Niewiadomski, A Gasiorowska… - Neural …, 2019 - Wiley Online Library
Physical training confers protection to dopaminergic neurons in rodent models of
parkinsonism produced by neurotoxins. The sparing effect of physical training on …

Neuroprotective brain-derived neurotrophic factor signaling in the TAU-P301L tauopathy zebrafish model

C Barbereau, A Yehya, M Silhol, N Cubedo… - Pharmacological …, 2020 - Elsevier
Brain-derived neurotrophic factor (BDNF) dysregulations contribute to the neurotoxicity in
neurodegenerative pathologies and could be efficiently targeted by therapies. In Alzheimer's …

Effects of mild running on substantia nigra during early neurodegeneration

MF Almeida, CM Silva, RS Chaves… - Journal of sports …, 2018 - Taylor & Francis
Moderate physical exercise acts at molecular and behavioural levels, such as interfering in
neuroplasticity, cell death, neurogenesis, cognition and motor functions. Therefore, the aim …

Mild exercise differently affects proteostasis and oxidative stress on motor areas during neurodegeneration: a comparative study of three treadmill running protocols

KP Melo, CM Silva, MF Almeida, RS Chaves… - Neurotoxicity …, 2019 - Springer
Proteostasis and oxidative stress were evaluated in motor cortex and spinal cord of aged
Lewis rats exposed to 1 mg/kg/day of rotenone during 4 or 8 weeks, prior or after practicing …

Involvement of Glucosamine 6 Phosphate Isomerase 2 (GNPDA2) Overproduction in β-Amyloid-and Tau P301L-Driven Pathomechanisms

M Lachén-Montes, P Cartas-Cejudo, A Cortés… - Biomolecules, 2024 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative olfactory disorder affecting millions of
people worldwide. Alterations in the hexosamine-or glucose-related pathways have been …

Restoration of Rab1 levels prevents endoplasmic reticulum stress in hippocampal cells during protein aggregation triggered by rotenone

NCR Lima, TQ Melo, AYS Sakugawa, KP Melo… - Neuroscience, 2019 - Elsevier
Disrupted neuronal intracellular trafficking is often related with protein aggregates present in
the brain during neurodegenerative diseases such as Alzheimer's. Impairment of …