Viral-like particles (VLPs) represent versatile nanoscale structures mimicking the
morphology and antigenic characteristics of viruses, devoid of genetic material, making them …

This work assessed the impact of laser wavelength and sample conditioning on offline
monitoring (viable cell density, cell viability, virus titer, glucose, lactate, glutamine, glutamate …

This paper presents a comprehensive study on the development of models and soft sensors
required for the implementation of the automated bioreactor feeding of Chinese hamster …

In the current biopharmaceutical scenario, constant bioprocess monitoring is crucial for the
quality and integrity of final products. Thus, process analytical techniques, such as those …

BACKGROUND This study aimed to establish chemometric models using Raman
spectroscopy data for biochemical monitoring of rabies Virus‐Like Particles (VLP) …

Virus-like particles (VLPs) are a promising class of biopharmaceuticals for vaccines and
targeted delivery. Starting from clarified lysate, VLPs are typically captured by selective …

Among vaccine platforms against SARS-CoV-2, the virus-like particles (VLP) hold
advantageous immunological and safety attributes. Furthermore, there are barriers to the …

The Zika disease caused by the Zika virus was declared a Public Health Emergency by the
World Health Union (WHO), with microcephaly as the most critical consequence. Aiming to …

This work aimed to set inline Raman spectroscopy models to monitor biochemically (viable
cell density, cell viability, glucose, lactate, glutamine, glutamate, and ammonium) all …

The present work focused on inline Raman spectroscopy monitoring of SARS-CoV-2 VLP
production using two culture media by fitting chemometric models for biochemical …