Alzheimer's pathogenic mechanisms and underlying sex difference

D Zhu, A Montagne, Z Zhao - Cellular and Molecular Life Sciences, 2021 - Springer
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

[HTML][HTML] Sex differences in Alzheimer's disease: insights from the multiomics landscape

L Guo, MB Zhong, L Zhang, B Zhang, D Cai - Biological psychiatry, 2022 - Elsevier
Alzheimer's disease (AD) has complex etiologies, and the impact of sex on AD varies over
the course of disease development. The literature provides some evidence of sex-specific …

Identification and immunological characterization of cuproptosis-related molecular clusters in Alzheimer's disease

Y Lai, C Lin, X Lin, L Wu, Y Zhao, F Lin - Frontiers in aging …, 2022 - frontiersin.org
Introduction Alzheimer's disease is the most common dementia with clinical and
pathological heterogeneity. Cuproptosis is a recently reported form of cell death, which …

Alzheimer's disease large-scale gene expression portrait identifies exercise as the top theoretical treatment

MA Hill, SC Gammie - Scientific reports, 2022 - nature.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder that affects multiple
brain regions and is difficult to treat. In this study we used 22 AD large-scale gene …

Complement-mediated synapse loss in Alzheimer's disease: mechanisms and involvement of risk factors

L Wen, D Bi, Y Shen - Trends in Neurosciences, 2024 - cell.com
The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …

Deep phenotyping of Alzheimer's disease leveraging electronic medical records identifies sex-specific clinical associations

AS Tang, T Oskotsky, S Havaldar, WG Mantyh… - Nature …, 2022 - nature.com
Alzheimer's Disease (AD) is a neurodegenerative disorder that is still not fully understood.
Sex modifies AD vulnerability, but the reasons for this are largely unknown. We utilize two …

Sex difference in biological change and mechanism of Alzheimer's disease: From macro-to micro-landscape

SS Cui, QW Jiang, SD Chen - Ageing Research Reviews, 2023 - Elsevier
Highlights•AD disproportionally affects women in the development, progression and clinical
presentation of AD.•Our review summarized sex differences in biological change of AD from …

Distinct sex-specific DNA methylation differences in Alzheimer's disease

T C. Silva, W Zhang, JI Young, L Gomez… - Alzheimer's research & …, 2022 - Springer
Background Sex is increasingly recognized as a significant factor contributing to the
biological and clinical heterogeneity in AD. There is also growing evidence for the prominent …

Expanding the scope of health disparities research in Alzheimer's disease and related dementias: Recommendations from the “Leveraging Existing Data and Analytic …

I Akushevich, J Kravchenko, A Yashkin… - Alzheimer's & …, 2023 - Wiley Online Library
Topics discussed at the “Leveraging Existing Data and Analytic Methods for Health
Disparities Research Related to Aging and Alzheimer's Disease and Related Dementias” …

Do microbes play a role in Alzheimer's disease?

ZAP Williams, L Lang, S Nicolas, G Clarke… - Microbial …, 2024 - Wiley Online Library
Alzheimer's disease is a complex and progressive condition that affects essential
neurological functions such as memory and reasoning. In the brain, neuronal loss, synaptic …