A review of FLT3 inhibitors in acute myeloid leukemia

JC Zhao, S Agarwal, H Ahmad, K Amin, JP Bewersdorf… - Blood reviews, 2022 - Elsevier
FLT3 mutations are the most common genetic aberrations found in acute myeloid leukemia
(AML) and associated with poor prognosis. Since the discovery of FLT3 mutations and their …

How I treat refractory and relapsed acute myeloid leukemia

F Thol, H Döhner, A Ganser - Blood, 2024 - ashpublications.org
Most patients with acute myeloid leukemia (AML) develop refractory/relapsed (R/R) disease
even in the presence of novel and targeted therapies. Given the biological complexity of the …

Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN

H Döhner, AH Wei, FR Appelbaum… - Blood, The Journal …, 2022 - ashpublications.org
The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …

DNA sequencing to detect residual disease in adults with acute myeloid leukemia prior to hematopoietic cell transplant

LW Dillon, G Gui, KM Page, N Ravindra, ZC Wong… - Jama, 2023 - jamanetwork.com
Importance Preventing relapse for adults with acute myeloid leukemia (AML) in first
remission is the most common indication for allogeneic hematopoietic cell transplant. The …

Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia

CA Lachowiez, N Long, J Saultz, A Gandhi… - Blood …, 2023 - ashpublications.org
Risk stratification in acute myeloid leukemia (AML) remains principle in survival
prognostication and treatment selection. The 2022 European LeukemiaNet (ELN) …

[HTML][HTML] The present and future of measurable residual disease testing in acute myeloid leukemia

JS Blachly, RB Walter, CS Hourigan - Haematologica, 2022 - ncbi.nlm.nih.gov
Considerable progress has been made in the past several years in the scientific
understanding of, and available treatments for, acute myeloid leukemia (AML). Achievement …

Management of acute myeloid leukemia: a review for general practitioners in oncology

RJ Stubbins, A Francis, F Kuchenbauer, D Sanford - Current oncology, 2022 - mdpi.com
Acute myeloid leukemia (AML) is a hematologic malignancy that most frequently develops in
older adults. Overall, AML is associated with a high mortality although advancements in …

Optical genome mapping for structural variation analysis in hematologic malignancies

AC Smith, K Neveling… - American journal of …, 2022 - Wiley Online Library
Optical genome mapping (OGM) is a technology that is rapidly being adopted in clinical
genetics laboratories for its ability to detect structural variation (eg, translocations …

Predictors of outcomes in adults with acute myeloid leukemia and KMT2A rearrangements

GC Issa, J Zarka, K Sasaki, W Qiao, D Pak, J Ning… - Blood cancer …, 2021 - nature.com
Acute myeloid leukemia (AML) with rearrangement of the lysine methyltransferase 2a gene
(KMT2Ar) has adverse outcomes. However, reports on the prognostic impact of various …

The role of tumor-associated macrophages in hematologic malignancies

E Cencini, A Fabbri, A Sicuranza, A Gozzetti… - Cancers, 2021 - mdpi.com
Simple Summary Tumor-associated macrophages (TAM) represent a leading component of
the tumor microenvironment in hematologic malignancies. TAM could display antitumor …