Circular RNA translation: novel protein isoforms and clinical significance

S Wen, J Qadir, BB Yang - Trends in molecular medicine, 2022 - cell.com
In recent years, significant attention has focused on circular RNA (circRNA) translation to
determine its clinical significance. Cap-independent translation of circRNAs driven by an …

New insight into circRNAs: characterization, strategies, and biomedical applications

XY Feng, SX Zhu, KJ Pu, HJ Huang, YQ Chen… - … Hematology & Oncology, 2023 - Springer
Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most
circRNAs are derived from exonic or intronic sequences by precursor RNA back-splicing …

Decoding the Non-coding: Tools and Databases Unveiling the Hidden World of “Junk” RNAs for Innovative Therapeutic Exploration

U Chaudhary, S Banerjee - ACS Pharmacology & Translational …, 2024 - ACS Publications
Non-coding RNAs are pivotal regulators of gene and protein expression, exerting crucial
influences on diverse biological processes. Their dysregulation is frequently implicated in …

Evaluation of methods to detect circular RNAs from single-end RNA-sequencing data

MH Nguyen, HN Nguyen, TN Vu - BMC genomics, 2022 - Springer
Abstract Background Circular RNA (circRNA), a class of RNA molecule with a loop structure,
has recently attracted researchers due to its diverse biological functions and potential …

Current advances in circular RNA detection and investigation methods: Are we running in circles?

R Drula, C Braicu… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Circular RNAs (circRNAs), characterized by their closed‐loop structure, have emerged as
significant transcriptomic regulators, with roles spanning from microRNA sponging to …

Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision

M Vromman, J Anckaert, S Bortoluzzi, A Buratin… - Nature …, 2023 - nature.com
The detection of circular RNA molecules (circRNAs) is typically based on short-read RNA
sequencing data processed using computational tools. Numerous such tools have been …

An integrative pipeline for circular RNA quantitative trait locus discovery with application in human T cells

DT Nguyen - Bioinformatics, 2023 - academic.oup.com
Motivation Molecular quantitative trait locus (QTL) mapping has proven to be a powerful
approach for prioritizing genetic regulatory variants and causal genes identified by genome …

CircNetVis: an interactive web application for visualizing interaction networks of circular RNAs

TH Nguyen, HN Nguyen, TN Vu - BMC bioinformatics, 2024 - Springer
Analyzing the interactions of circular RNAs (circRNAs) is a crucial step in understanding
their functional impacts. While there are numerous visualization tools available for …

Computational approaches for circRNAs prediction and in silico characterization

C Rebolledo, JP Silva, N Saavedra… - Briefings in …, 2023 - academic.oup.com
Circular RNAs (circRNAs) are single-stranded and covalently closed non-coding RNA
molecules originated from RNA splicing. Their functions include regulatory potential over …

Accurate Assembly of Circular RNAs with TERRACE

T Zahin, Q Shi, XC Zang, M Shao - International Conference on Research …, 2024 - Springer
Circular RNA (circRNA) is a class of RNA molecules that forms a closed loop with its 5'and
3'ends covalently bonded. CircRNAs were severely overlooked previously owing to the …