Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

For many years, amino acid‐specific covalent labeling has been a valuable tool to study
protein structure and protein interactions, especially for systems that are difficult to study by …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Transcription and its dynamics are crucial for gene expression regulation. However, very few
methods can directly read out transcriptional activity with low-input material and high …

Chemical probing represents a very versatile alternative for studying the structure and
dynamics of substrates that are intractable by established high‐resolution techniques. The …

This report illustrates the approaches employed to investigate critical aspects of the activity
of crosslinking reagents toward nucleic acid substrates, which should be evaluated to …

Among all enzymes in nature, RNase P is unique in that it can use either an RNA-or a
protein-based active site for its function: catalyzing cleavage of the 5′-leader from …

The combination of chemical probing and high-resolution mass spectrometry constitutes a
powerful alternative for the structural elucidation of biomolecules possessing unfavorable …

Arginine residues undergo several kinds of post-translational modifications (PTMs). These
PTMs are associated with several inflammatory diseases, such as rheumatoid arthritis …

Examining the chemical modification of biological polymers and the emerging applications
of this technology, Chemical Modification of Biological Polymers reflects the change in …