CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome

S Arcangeli, C Bove, C Mezzanotte… - The Journal of …, 2022 - Am Soc Clin Investig
Chimeric antigen receptor (CAR) T cell expansion and persistence represent key factors to
achieve complete responses and prevent relapses. These features are typical of early …

[HTML][HTML] International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): non-proliferative and proliferative lesions of the non-human primate (M …

K Colman, RN Andrews, H Atkins… - Journal of toxicologic …, 2021 - ncbi.nlm.nih.gov
Abstract The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria
for Lesions Project (www. toxpath. org/inhand. asp) is a joint initiative of the Societies of …

relevant conditions and pathology of laboratory mice, rats, gerbils, Guinea pigs, hamsters, naked mole rats, and rabbits

TK Cooper, DK Meyerholz, AP Beck, MA Delaney… - ILAR …, 2021 - academic.oup.com
Animals are valuable resources in biomedical research in investigations of biological
processes, disease pathogenesis, therapeutic interventions, safety, toxicity, and …

[HTML][HTML] Protective effect of novel angiotensin receptor neprilysin inhibitor S086 on target organ injury in spontaneously hypertensive rats

Y Xiao, ZY Zhou, JC Sun, W Xing, J Yan, WJ Xu… - Biomedicine & …, 2024 - Elsevier
Background Hypertension is a clinical syndrome characterized by elevated systemic arterial
blood pressure associated with injury to the heart, kidney, brain, and other organs …

Scientific and Regulatory Policy Committee technical review: biology and pathology of ganglia in animal species used for nonclinical safety testing

BM Bennet, ID Pardo, BT Assaf, E Buza… - Toxicologic …, 2023 - journals.sagepub.com
Dorsal root ganglia (DRG), trigeminal ganglia (TG), other sensory ganglia, and autonomic
ganglia may be injured by some test article classes, including anti-neoplastic …

Scientific and Regulatory Policy Committee points to consider: sampling, processing, evaluation, interpretation, and reporting of test article-related ganglion pathology …

BM Bennet, ID Pardo, BT Assaf, E Buza… - Toxicologic …, 2023 - journals.sagepub.com
Certain biopharmaceutical products consistently affect dorsal root ganglia, trigeminal
ganglia, and/or autonomic ganglia. Product classes targeting ganglia include antineoplastic …

Toxicologic Pathology Forum opinion: interpretation of gliosis in the brain and spinal cord observed during nonclinical safety studies

B Bolon - Toxicologic pathology, 2023 - journals.sagepub.com
Gliosis, defined as a nonneoplastic reaction (hypertrophy and/or proliferation) of astrocytes
and/or microglial cells, is a frequent finding in the central nervous system (CNS [brain and/or …

International harmonization of nomenclature and diagnostic criteria (INHAND): nonproliferative and proliferative lesions of the minipig

M Skydsgaard, Z Dincer, WM Haschek… - Toxicologic …, 2021 - journals.sagepub.com
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for
Lesions) Project (www. toxpath. org/inhand. asp) is a joint initiative of the Societies of …

Society of Toxicologic Pathology Neuropathology Interest Group article: neuropathologic findings in nonhuman primates associated with administration of biomolecule …

DS Bangari, LG Lanigan, F Goulet… - Toxicologic …, 2022 - journals.sagepub.com
The increasing specificity of novel druggable targets coupled with the complexity of
emerging therapeutic modalities for treating human diseases has created a growing need …

Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene …

AM Brooks, A Vornoli, RC Kovi, TVT Ton, M Xu… - Plos one, 2024 - journals.plos.org
The cancer hazard associated with lifetime exposure to radiofrequency radiation (RFR) was
examined in Sprague Dawley (SD) rats at the Ramazzini Institute (RI), Italy. There were …