An overview of experimental designs in HPLC method development and validation

PK Sahu, NR Ramisetti, T Cecchi, S Swain… - … of pharmaceutical and …, 2018 - Elsevier
Chemometric approaches have been increasingly viewed as precious complements to high
performance liquid chromatographic practices, since a large number of variables can be …

Youden test application in robustness assays during method validation

E Karageorgou, V Samanidou - Journal of Chromatography A, 2014 - Elsevier
Analytical method validation is a vital step following method development for ensuring
reliable and accurate method performance. Among examined figures of merit, robustness …

[HTML][HTML] A fast and simple LC-ESI-MS/MS method for detecting pyrrolizidine alkaloids in honey with full validation and measurement uncertainty

AC Valese, L Molognoni, LA de Sá Ploêncio… - Food Control, 2016 - Elsevier
A fast and simple method was developed to determine pyrrolizidine alkaloids (PAs) in honey
using liquid chromatography tandem mass spectrometry (LC-MS/MS) with electrospray …

Direct liquid chromatography method for the simultaneous quantification of hydroxytyrosol and tyrosol in red wines

Z Piñeiro, E Cantos-Villar, M Palma… - Journal of agricultural …, 2011 - ACS Publications
A validated HPLC method with fluorescence detection for the simultaneous quantification of
hydroxytyrosol and tyrosol in red wines is described. Detection conditions for both …

[HTML][HTML] A validated NMR approach for MDMA quantification in ecstasy tablets

NS Almeida, LEC Benedito, AO Maldaner… - Journal of the Brazilian …, 2018 - SciELO Brasil
In recent years, ecstasy trafficking has grown in complexity and tablets has been commonly
sold containing different contents of 3, 4-methylenedioxymethamphetamine (MDMA) or even …

Validation and application of liquid chromatography coupled with tandem mass spectrometry method for the analysis of glyphosate, aminomethylphosphonic acid …

JB Leyva-Morales, R Cabrera, PJ Bastidas-Bastidas… - Agriculture, 2023 - mdpi.com
A method was developed to determine glyphosate, aminomethylphosphonic acid (AMPA),
and glufosinate in soil. The worldwide use of this herbicide in agricultural activities, and its …

R. Graph: A new risk-based causal reasoning and its application to COVID-19 risk analysis

H Seiti, A Makui, A Hafezalkotob, M Khalaj… - Process Safety and …, 2022 - Elsevier
Various unexpected, low-probability events can have short or long-term effects on
organizations and the global economy. Hence there is a need for appropriate risk …

Toltrazuril+ fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes

DMB Zapa, LM Heller, LM de Aquino… - … : Regional Studies and …, 2024 - Elsevier
The present work evaluated the pharmacokinetics and efficacy of the association of
15cmg/kg toltrazuril+ 5cmg/kg fenbendazole against Eimeria spp. and gastrointestinal …

Optimization and validation in liquid chromatography using design of experiments

L Latrous - Chemistry Africa, 2022 - Springer
Faced to the large number of potential factors in liquid chromatography, the analyst is often
led to determine through his experience the parameters to be studied. Experimental designs …

An easy and rapid spectrophotometric method for determination of chloroquine diphosphate in tablets

MA Castro e Souza, NFA Reis… - Current …, 2020 - ingentaconnect.com
Introduction: Malaria, an infectious disease caused by protozoa of the genus Plasmodium, is
highly prevalent in the Brazilian Amazon. Chloroquine is the first-choice drug for the …