Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Recent studies uncovered important core/periphery network structures characterizing
complex sets of cooperative and competitive interactions between network nodes, be they …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently affects
36 million people worldwide with no effective treatment available. Development of AD …

Correlations among plant traits often reflect important trade‐offs or allometric relationships in
biological functions like carbon gain, support, water uptake, and reproduction that are …

Structural and biochemical studies of the severe acute respiratory syndrome (SARS)-CoV-2
spike glycoproteins and complexes with highly potent antibodies have revealed multiple …

The development of computational strategies for the quantitative characterization of the
functional mechanisms of SARS-CoV-2 spike proteins is of paramount importance in efforts …

The rapidly growing body of structural and biochemical studies of the SARS-CoV-2 spike
glycoprotein has revealed a variety of distinct functional states with radically different …

The network model of psychopathology suggests that central and bridge symptoms
represent promising treatment targets because they may accelerate the deactivation of the …

The inflammatory responses of vascular endothelial cells (VECs) are critical in the
development of many cardio-cerebrovascular diseases. Let-7e is an important regulator of …

The human kinome is gaining importance through its promising cancer therapeutic targets,
yet no general model to address the kinase inhibitor resistance has emerged. Here, we …