At implantation, the embryo expresses paternally derived alloantigens and evokes
inflammation that can threaten reproductive success. To ensure a robust placenta and …

In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …

Immunological identity is traditionally defined by genetically encoded antigens, with equal
maternal and paternal contributions as a result of Mendelian inheritance. However, vertically …

Cervicovaginal microbiota play a critical role in women's health and reproductive outcomes.
Despite being one of the simplest commensal bacterial communities in the human body, we …

Regulatory T cells (Tregs) have been exhaustively investigated during early pregnancy;
however, their role later in gestation is poorly understood. Herein, we report that functional …

The maternal immune system plays a critical role in the establishment, maintenance, and
completion of a healthy pregnancy. However, the specific mechanisms utilized to achieve …

Regulatory T cells, a subpopulation of suppressive T cells, are potent mediators of self-
tolerance and essential for the suppression of triggered immune responses. The immune …

Immune cells are essential for endometrial receptivity to embryo implantation and early
placental development. They exert tissue-remodeling and immune regulatory roles—acting …

Preterm labor commonly precedes preterm birth, the leading cause of perinatal morbidity
and mortality worldwide. Most research has focused on establishing a causal link between …