Abstract Cyclin-dependent kinase 9 (CDK9), the kinase component of positive transcription
elongation factor b (P-TEFb), is essential for transcription of most protein-coding genes by …

Tandem transcription interference occurs when the act of transcription from an upstream
promoter suppresses utilization of a co-oriented downstream promoter. Because eukaryal …

Control of transcription speed, which influences many co-transcriptional processes, is poorly
understood. We report that PNUTS-PP1 phosphatase is a negative regulator of RNA …

R-loops, which result from the formation of stable DNA: RNA hybrids, can both threaten
genome integrity and act as physiological regulators of gene expression and chromatin …

The end of the RNA polymerase II (Pol II) transcription cycle is strictly regulated to prevent
interference between neighbouring genes and to safeguard transcriptome integrity. The …

The transcription cycle of RNA polymerase II (Pol II) is regulated at discrete transition points
by cyclin-dependent kinases (CDKs). Positive transcription elongation factor b (P-TEFb), a …

Termination of RNA polymerase II (Pol II) transcription is a key step that is important for 3′
end formation of functional mRNA, mRNA release, and Pol II recycling. Even so, the …

Upon recruitment to active enhancers and promoters, RNA polymerase II (Pol II) generates
short non-coding transcripts of unclear function. The mechanisms that control the length and …

Reversible phosphorylation of Pol II and accessory factors helps order the transcription
cycle. Here, we define two kinase-phosphatase switches that operate at different points in …

The transcription cycle of RNA polymerase II (RNAPII) is governed at multiple points by
opposing actions of cyclin-dependent kinases (CDKs) and protein phosphatases, in a …