[HTML][HTML] Role of regulator of G protein signaling proteins in bone
Regulators of G protein signaling (RGS) proteins are a family with more than 30 proteins that
all contain an RGS domain. In the past decade, increasing evidence has indicated that RGS …
all contain an RGS domain. In the past decade, increasing evidence has indicated that RGS …
Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells
O Bromberg, BJ Frisch, JM Weber… - Blood, The Journal …, 2012 - ashpublications.org
Hematopoietic stem cell (HSC) regulation is highly dependent on interactions with the
marrow microenvironment. Controversy exists on N-cadherin's role in support of HSCs …
marrow microenvironment. Controversy exists on N-cadherin's role in support of HSCs …
Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche
Two decades after signals controlling bone length were discovered, the endogenous
ligands determining bone width remain unknown. We show that postnatal establishment of …
ligands determining bone width remain unknown. We show that postnatal establishment of …
Gs/Gi regulation of bone cell differentiation: review and insights from engineered receptors
EC Hsiao, SM Millard… - Hormone and Metabolic …, 2016 - thieme-connect.com
G-protein coupled receptors (GPCRs) and their ligands are critical for normal osteoblast
formation and function. GPCRs mediate a wide variety of biological processes and are …
formation and function. GPCRs mediate a wide variety of biological processes and are …
[HTML][HTML] Targeting Gi/o protein–coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy
GPCRs are highly desirable drug targets for human disease. Although GPCR dysfunction
drives development and progression of many tumors, including breast cancer (BC), targeting …
drives development and progression of many tumors, including breast cancer (BC), targeting …
Increased bone mass in mice lacking the adipokine apelin
L Wattanachanya, WD Lu, RK Kundu, L Wang… - …, 2013 - academic.oup.com
Adipose tissue plays an important role in skeletal homeostasis, and there is interest in
identifying adipokines that influence bone mass. One such adipokine may be apelin, a …
identifying adipokines that influence bone mass. One such adipokine may be apelin, a …
Increased osteoblast GαS level determines bone response to hyperparathyroidism in female mice
L Zhang, KK Lee, KS Sugamori… - Journal of …, 2022 - joe.bioscientifica.com
GS, the stimulatory heterotrimeric G protein, is an essential regulator of osteogenesis and
bone turnover. To determine if increasing Gα S in osteoblasts alters bone responses to …
bone turnover. To determine if increasing Gα S in osteoblasts alters bone responses to …
Osteoblast-derived FGF9 regulates skeletal homeostasis
FGF9 has complex and important roles in skeletal development and repair. We have
previously observed that Fgf9 expression in osteoblasts (OBs) is regulated by G protein …
previously observed that Fgf9 expression in osteoblasts (OBs) is regulated by G protein …
Loss of Gi G‐Protein‐Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing
L Wang, EC Hsiao, S Lieu, M Scott… - Journal of Bone and …, 2015 - academic.oup.com
ABSTRACT G‐protein‐coupled receptors (GPCRs) are key regulators of skeletal
homeostasis and are likely important in fracture healing. Because GPCRs can activate …
homeostasis and are likely important in fracture healing. Because GPCRs can activate …
Negative skeletal effects of locally produced adiponectin
Epidemiological studies show that high circulating levels of adiponectin are associated with
low bone mineral density. The effect of adiponectin on skeletal homeostasis, on osteoblasts …
low bone mineral density. The effect of adiponectin on skeletal homeostasis, on osteoblasts …