The clearance of dead cells by efferocytosis
E Boada-Romero, J Martinez, BL Heckmann… - … reviews Molecular cell …, 2020 - nature.com
Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …
induced in a setting-dependent manner. As billions of cells die during mammalian …
[HTML][HTML] Nrf2-Keap1 signaling in oxidative and reductive stress
I Bellezza, I Giambanco, A Minelli, R Donato - Biochimica et Biophysica …, 2018 - Elsevier
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved
intracellular defense mechanism to counteract oxidative stress. Sequestered by cytoplasmic …
intracellular defense mechanism to counteract oxidative stress. Sequestered by cytoplasmic …
Functions of S100 proteins
The S100 protein family consists of 24 members functionally distributed into three main
subgroups: those that only exert intracellular regulatory effects, those with intracellular and …
subgroups: those that only exert intracellular regulatory effects, those with intracellular and …
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
The elderly often suffer from progressive muscle weakness and regenerative failure. We
demonstrate that muscle regeneration is impaired with aging owing in part to a cell …
demonstrate that muscle regeneration is impaired with aging owing in part to a cell …
Engineered in vitro disease models
The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …
human disease or to develop new and improved therapies or diagnostics. Although great …
Does skeletal muscle have an 'epi'‐memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise
AP Sharples, CE Stewart, RA Seaborne - Aging cell, 2016 - Wiley Online Library
Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle
performance, maintaining metabolic function and supporting longevity and healthspan …
performance, maintaining metabolic function and supporting longevity and healthspan …
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake
Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and
function. Given the worldwide aging demographics, this is a major contributor to morbidity …
function. Given the worldwide aging demographics, this is a major contributor to morbidity …
[HTML][HTML] RAGE in tissue homeostasis, repair and regeneration
RAGE (receptor for advanced glycation end-products) is a multiligand receptor of the
immunoglobulin superfamily involved in inflammation, diabetes, atherosclerosis …
immunoglobulin superfamily involved in inflammation, diabetes, atherosclerosis …
DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity
Skeletal muscle tissue demonstrates global hypermethylation with age. However,
methylome changes across the time-course of differentiation in aged human muscle derived …
methylome changes across the time-course of differentiation in aged human muscle derived …
S100A6 protein: functional roles
R Donato, G Sorci, I Giambanco - Cellular and Molecular Life Sciences, 2017 - Springer
S100A6 protein belongs to the A group of the S100 protein family of Ca 2+-binding proteins.
It is expressed in a limited number of cell types in adult normal tissues and in several tumor …
It is expressed in a limited number of cell types in adult normal tissues and in several tumor …