Possible adverse effects of high-dose nicotinamide: mechanisms and safety assessment

ES Hwang, SB Song - Biomolecules, 2020 - mdpi.com
Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be
effective against a wide spectrum of diseases and conditions, including neurological …

Placental mitochondrial function and dysfunction in preeclampsia

F Jahan, G Vasam, AE Green, SA Bainbridge… - International journal of …, 2023 - mdpi.com
The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational
parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in …

[HTML][HTML] Nicotinamide as a foundation for treating neurodegenerative disease and metabolic disorders

K Maiese - Current neurovascular research, 2021 - ncbi.nlm.nih.gov
Neurodegenerative disorders impact more than one billion individuals worldwide and are
intimately tied to metabolic disease that can affect another nine hundred individuals …

[HTML][HTML] New Insights for nicotinamide: Metabolic disease, autophagy, and mTOR

K Maiese - Frontiers in bioscience (Landmark edition), 2020 - ncbi.nlm.nih.gov
Metabolic disorders, such as diabetes mellitus (DM), are increasingly becoming significant
risk factors for the health of the global population and consume substantial portions of the …

Preclinical models of acute liver failure: a comprehensive review

J Hefler, BA Marfil-Garza, RL Pawlick, DH Freed… - PeerJ, 2021 - peerj.com
Acute liver failure is marked by the rapid deterioration of liver function in a previously well
patient over period of days to weeks. Though relatively rare, it is associated with high …

Nicotinamide: oversight of metabolic dysfunction through sirt1, mtor, and clock genes

K Maiese - Current neurovascular research, 2020 - ingentaconnect.com
Metabolic disorders that include diabetes mellitus present significant challenges for
maintaining the welfare of the global population. Metabolic diseases impact all systems of …

Cornerstone Cellular pathways for metabolic disorders and Diabetes Mellitus: non-coding RNAs, wnt signaling, and AMPK

K Maiese - Cells, 2023 - mdpi.com
Metabolic disorders and diabetes (DM) impact more than five hundred million individuals
throughout the world and are insidious in onset, chronic in nature, and yield significant …

[HTML][HTML] Phoenix dactylifera protects against oxidative stress and hepatic injury induced by paracetamol intoxication in rats

GA Salem, A Shaban, HA Diab, WA Elsaghayer… - Biomedicine & …, 2018 - Elsevier
The current studies were sought to determine effects of antioxidant potential of aqueous and
methanolic extracts of Phoenix dactylifera leaves (PLAE and PLME) against the widely-used …

Potential effects of the combination of nicotinamide, vitamin B2 and vitamin C on oxidative-mediated hepatotoxicity induced by thioacetamide

SAE Bashandy, H Ebaid… - Lipids in health and …, 2018 - Springer
Background The liver disease is one of the most important traditional public health problems
in Egypt. Oxidative stress is attributed to such pathological condition that further contributes …

Integrated network pharmacology, transcriptomics and metabolomics to explore the material basis and mechanism of Danggui-Baishao herb pair for treating hepatic …

Z Zhang, G Wu, J Yang, X Liu, Z Chen, D Liu… - Journal of …, 2025 - Elsevier
Abstract Ethnopharmacological relevance The Danggui-Baishao herb pair (DB) is
commonly used as Chinese herbal formulas for treating hepatic fibrosis (HF). However …