DExH/D-box helicases at the frontline of intrinsic and innate immunity against viral infections

B Bonaventure, C Goujon - Journal of General Virology, 2022 - microbiologyresearch.org
DExH/D-box helicases are essential nucleic acid and ribonucleoprotein remodelers
involved in all aspects of nucleic acid metabolism including replication, gene expression …

Anti-influenza A virus restriction factors that shape the human species barrier and virus evolution

PP Petric, M Schwemmle, L Graf - PLoS Pathogens, 2023 - journals.plos.org
Zoonotic infections with influenza A viruses (IAVs) of avian origin can cause severe disease
with high fatality in humans, as in the case of the avian IAV subtypes H5N1 and H7N9 …

An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses

J McKellar, M Arnaud-Arnould, L Chaloin… - Journal of Biological …, 2023 - ASBMB
Myxovirus resistance protein 1 (MX1) and MX2 are homologous, dynamin-like large
GTPases, induced upon interferon exposure. Human MX1 (HsMX1) is known to inhibit many …

Long noncoding RNAs in respiratory viruses: A review

MM Kesheh, S Mahmoudvand… - Reviews in Medical …, 2022 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are defined as RNA molecules longer than 200
nucleotides that can regulate gene expression at the transcriptional or post‐transcriptional …

Omicron‐induced interferon signaling prevents influenza A H1N1 and H5N1 virus infection

D Bojkova, M Bechtel, T Rothenburger… - Journal of Medical …, 2023 - Wiley Online Library
Recent findings in permanent cell lines suggested that SARS‐CoV‐2 Omicron BA. 1 induces
a stronger interferon response than Delta. Here, we show that BA. 1 and BA. 5 but not Delta …

Peering into avian influenza a (H5N8) for a framework towards pandemic preparedness

JY Yeo, SKE Gan - Viruses, 2021 - mdpi.com
2014 marked the first emergence of avian influenza A (H5N8) in Jeonbuk Province, South
Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak …

Increased polymerase activity of zoonotic H7N9 allows partial escape from MxA

PP Petric, J King, L Graf, A Pohlmann, M Beer… - Viruses, 2022 - mdpi.com
The interferon-induced myxovirus resistance protein A (MxA) is a potent restriction factor that
prevents zoonotic infection from influenza A virus (IAV) subtype H7N9. Individuals …

Dr Jekyll and Mr Hyde: From Two Branches of Immune Response to Three Types of Interferon Response

B Brown - 2023 - preprints.org
Interferons were the original prototype cytokine system discovered during research of the 20
th century. As the name suggests these were originally considered to be synthesised and …

The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 Infection

B Wang, H Zheng, X Dong, W Zhang… - International Journal …, 2024 - Wiley Online Library
Influenza pandemic with H1N1 (H1N1pdms) causes severe lung damage and “cytokine
storm,” leading to higher mortality and global health emergencies in humans and animals …

[PDF][PDF] Infection-Simulator, Immunostimulatory and Immunomodulatory Effects of Interferons I and III in Biological Systems: A New Era in Vaccinology and Therapeutics …

TN Carp, M Metoudi, V Ojha - 2024 - preprints.org
The severe acquired respiratory coronavirus–2 (SARS–CoV-2) infection has initiated both
acute and chronic COVID–19 disease between 2020 and 2023, currently evolving with other …