Photopharmacology is an attractive approach for achieving targeted drug action with the use
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …

Human carbonic anhydrases (hCAs) are widespread zinc enzymes that catalyze the
hydration of CO2 to bicarbonate and a proton. Currently, 15 isoforms have been identified, of …

Two azobenzenesulfonamide molecules with thermally stable cis configurations resulting
from fluorination of positions ortho to the azo group are reported that can differentially …

The stimuli-responsive nano-carriers are at the forefront of research in nanotechnology and
materials science. These advanced systems are designed to alter their physicochemical …

Photochemical regulation provides a promising approach for controlling enzyme activity on
demand owing to its high spatiotemporal resolution. However, reversible regulation of the …

Metalloenzymes are responsible for numerous physiological and pathological processes in
living organisms; however, there are very few FDA-approved metalloenzyme-targeting …

Enzymes are important macromolecular biocatalysts that accelerate chemical and
biochemical reactions in living organisms. Most human diseases are related to alterations in …

Light-triggered chemical reactions can provide excellent tools to investigate the fundamental
mechanisms important in biology. Light is easily applicable and orthogonal to most cellular …

The carbonic anhydrase (CA) enzyme reversibly transforms carbon dioxide and water to a
carbonate ion and a proton. Photoresponsive enzyme mimics, where the CA-activity can be …

Photochemical regulation provides precise control over enzyme activities with high
spatiotemporal resolution. A promising approach involves anchoring “photoswitches” at …