Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory
PD-L1 on the surface of tumor cells binds its receptor PD-1 on effector T cells, thereby
suppressing their activity. Antibody blockade of PD-L1 can activate an anti-tumor immune …
suppressing their activity. Antibody blockade of PD-L1 can activate an anti-tumor immune …
Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research
T Ferreira, A Gama, F Seixas, AI Faustino-Rocha… - Veterinary …, 2023 - mdpi.com
Simple Summary Breast cancer research is frequently performed using a variety of models,
including animal models, in an attempt to provide information that can be translated into …
including animal models, in an attempt to provide information that can be translated into …
Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment
AJ Petty, A Li, X Wang, R Dai… - The Journal of …, 2019 - Am Soc Clin Investig
Tumor-associated macrophages (TAMs) usually display an antiinflammatory M2-like
phenotype to facilitate tumor growth. However, what drives M2 polarization of TAMs and how …
phenotype to facilitate tumor growth. However, what drives M2 polarization of TAMs and how …
[HTML][HTML] Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer
Photodynamic therapy (PDT) to manage non-melanoma skin cancers has garnered great
attention over the past few years. Hypericin (Hy) is a potent lipid-soluble photosensitiser with …
attention over the past few years. Hypericin (Hy) is a potent lipid-soluble photosensitiser with …
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation
M Boieri, A Malishkevich, R Guennoun… - Journal of Experimental …, 2022 - rupress.org
Cancer immunology research is largely focused on the role of cytotoxic immune responses
against advanced cancers. Herein, we demonstrate that CD4+ T helper (Th2) cells directly …
against advanced cancers. Herein, we demonstrate that CD4+ T helper (Th2) cells directly …
Framework nucleic acids as programmable carrier for transdermal drug delivery
DNA nanostructures are promising drug carriers with their intrinsic biocompatibility,
uniformity and versatility. However, rapid serum disintegration leads to low bioavailability at …
uniformity and versatility. However, rapid serum disintegration leads to low bioavailability at …
Liposomal delivery of mitoxantrone and a cholesteryl indoximod prodrug provides effective chemo-immunotherapy in multiple solid tumors
We developed a custom-designed liposome carrier for codelivery of a potent immunogenic
cell death (ICD) stimulus plus an inhibitor of the indoleamine 2, 3-dioxygenase (IDO-1) …
cell death (ICD) stimulus plus an inhibitor of the indoleamine 2, 3-dioxygenase (IDO-1) …
[HTML][HTML] Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
Cross-presentation of antigens from dead tumor cells by type 1 conventional dendritic cells
(cDC1s) is thought to underlie priming of anti-cancer CD8+ T cells. cDC1 express high …
(cDC1s) is thought to underlie priming of anti-cancer CD8+ T cells. cDC1 express high …
N-Methyl-N-nitrosourea as a mammary carcinogenic agent
The administration of chemical carcinogens is one of the most commonly used methods to
induce tumors in several organs in laboratory animals in order to study oncologic diseases …
induce tumors in several organs in laboratory animals in order to study oncologic diseases …
A small molecule targeting mutagenic translesion synthesis improves chemotherapy
Intrinsic and acquired drug resistance and induction of secondary malignancies limit
successful chemotherapy. Because mutagenic translesion synthesis (TLS) contributes to …
successful chemotherapy. Because mutagenic translesion synthesis (TLS) contributes to …