Oncolytic viruses (OVs) provide novel and promising therapeutic options for patients with
cancers resistant to traditional therapies. Natural or genetically modified OVs are …

Oncolytic viruses represent a new class of therapeutic agents that promote anti-tumour
responses through a dual mechanism of action that is dependent on selective tumour cell …

Importance Oncolytic viruses (OVs) are emerging as important agents in cancer treatment.
Oncolytic viruses offer the attractive therapeutic combination of tumor-specific cell lysis …

Triple-negative breast cancer (TNBC) is an aggressive disease for which treatment options
are limited and associated with severe toxicities. Immunotherapeutic approaches like …

Preexisting lymphocytic infiltration of tumors is associated with superior prognostic outcomes
in a variety of cancers. Recent studies also suggest that lymphocytic responses may identify …

Applications of viral vectors have found an encouraging new beginning in gene therapy in
recent years. Significant improvements in vector engineering, delivery, and safety have …

Background Due to the lack of protective immunity of humans towards the newly emerged
SARS-CoV-2, this virus has caused a massive pandemic across the world resulting in …

Purpose: To conduct a phase I clinical trial with a second-generation oncolytic herpes
simplex virus (HSV) expressing granulocyte macrophage colony-stimulating factor (Onco …

In the past 5 years, the field of oncolytic virus research has matured significantly and is
moving past the stage of being a laboratory novelty into a new era of preclinical and clinical …

We undertook a Phase I/II trial in patients with apparent recurrent glioblastoma multiforme
(GBM) based on imaging studies to determine the safety and tumor response of repetitive …