[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals

R Furrer, JA Hawley, C Handschin - Physiological Reviews, 2023 - journals.physiology.org
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

[HTML][HTML] Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation

E Giacomelli, BF Vahsen, EL Calder, Y Xu, J Scaber… - Cell Stem Cell, 2022 - cell.com
Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

A harmonized atlas of mouse spinal cord cell types and their spatial organization

DE Russ, RBP Cross, L Li, SC Koch… - Nature …, 2021 - nature.com
Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

[HTML][HTML] A cellular taxonomy of the adult human spinal cord

A Yadav, KJE Matson, L Li, I Hua, J Petrescu, K Kang… - Neuron, 2023 - cell.com
The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …

Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons

JA Blum, S Klemm, JL Shadrach, KA Guttenplan… - Nature …, 2021 - nature.com
The spinal cord is a fascinating structure that is responsible for coordinating movement in
vertebrates. Spinal motor neurons control muscle activity by transmitting signals from the …

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

KJE Matson, DE Russ, C Kathe, I Hua, D Maric… - Nature …, 2022 - nature.com
After spinal cord injury, tissue distal to the lesion contains undamaged cells that could
support or augment recovery. Targeting these cells requires a clearer understanding of their …

Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson's disease-like neurodegeneration by causing energy …

B Liang, Y Huang, Y Zhong, Z Li, R Ye, B Wang… - Journal of Hazardous …, 2022 - Elsevier
With the prevalence of nanoplastics in daily life, human exposure is inevitable. However,
whether and how nanoplastics cause neurotoxicity in humans remains obscure. Herein, we …

Molecular blueprints for spinal circuit modules controlling locomotor speed in zebrafish

I Pallucchi, M Bertuzzi, D Madrid, P Fontanel… - Nature …, 2024 - nature.com
The flexibility of motor actions is ingrained in the diversity of neurons and how they are
organized into functional circuit modules, yet our knowledge of the molecular underpinning …

Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

MR Ananth, P Rajebhosale, R Kim… - Nature Reviews …, 2023 - nature.com
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury

Y Fan, X Wu, S Han, Q Zhang, Z Sun, B Chen… - Nature …, 2023 - nature.com
Spinal cord injury (SCI) leads to severe sensory and motor dysfunction below the lesion.
However, the cellular dynamic responses and heterogeneity across different regions below …